Evidence map›Paper›PMID 37229914›Full record

SynthesisVirology2023

Clinical virology and effect of Covid-19 vaccination and monoclonal antibodies against highly infectious SARS- CoV-2 omicron sub variant BF.7 (BA.5.2.1.7): A systematic review.

Santenna Chenchula, Krishna Chaitanya Amerneni, Mohan Krishna Ghanta, R Padmavathi, Madhu Bhargavi Chandra, Madhu Babu Adusumilli, Madhavrao Chavan, Sofia Mudda, Rupesh Gupta, Bhawna Lakhawat

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Santenna ChenchulaDepartment of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India. Electronic address: csanten7@gmail.com.
Krishna Chaitanya AmerneniDepartment of Internal Medicine, Western Michigan University, Kalamazoo, MI, USA. Electronic address: krishnachaitanya.amerneni@med.wmich.edu.
Mohan Krishna GhantaDepartment of Pharmacology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, India. Electronic address: mohanakrishna.ghanta@gmail.com.
R PadmavathiSVS Medical College and Hospital, Telangana, India. Electronic address: pad.mythili@gmail.com.
Madhu Bhargavi ChandraAll India Institute of Medical Sciences, Bhopal, India. Electronic address: madhubhargavi196@gmail.com.
Madhu Babu AdusumilliAll India Institute of Medical Sciences, Bhopal, India. Electronic address: madhu.adusumilli3@gmail.com.
Madhavrao ChavanDepartment of Pharmacology, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India. Electronic address: madhavrao.pharm@aiimsmangalagiri.edu.in.
Sofia MuddaAll India Institute of Medical Sciences, Bhopal, India. Electronic address: sophia.dr@gmail.com.
Rupesh GuptaDepartment of Internal Medicine, Government Medical College, Shahdol, Madhya Pradesh, India. Electronic address: neolog.raj@gmail.com.
Bhawna LakhawatDepartment of Pharmacology, All India Institute of Medical Sciences, Bhopal, India. Electronic address: bhawnaajmer001@gmail.com.
All India Institute of Medical Sciences Bhopal · INAll India Institute of Medical Sciences Raipur · INGovernment Medical College · INMVJ Medical College and Research Hospital · INSVS Medical College · INWestern Michigan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over time, the SARS-CoV-2 virus has acquired several genetic mutations, particularly on the receptor-binding domain (RBD) spike glycoprotein. The Omicron variant is highly infectious, with enhanced immune escape activity, and has given rise to various sub-lineages due to mutations. However, there has been a sudden increase in COVID-19 reports of the Omicron subvariant BF.7 (BA.2.75.2), which has the highest number of reported cases, accounting for 76.2% of all cases worldwide. Hence, the present systematic review aimed to understand the viral mutations and factors associated with the increase in the reports of COVID-19 cases and to assess the effectiveness of vaccines and mAbs against the novel Omicron variant BF.7. The R346T mutation on the spike glycoprotein RBD might be associated with increased infection rates, severity, and resistance to vaccines and mAbs. Booster doses of COVID-19 vaccination with bivalent mRNA booster vaccine shots are effective in curtailing infections and decreasing the severity and mortality by enhancing the neutralizing antibodies (Abs) against the emerging Omicron subvariants of SARS-CoV-2, including BF.7 and future VOCs.

Indexed as

COVID-19COVID-19 VaccinesAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralGlycoproteinsHumansSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccines, CombinedAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesGlycoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, CombinedBA.2.75.2BF.7Covid-19 VaccinesOmicronSARS-CoV-2Variant of concern

Identifiers

PMID37229914
PMCPMC10197433
OpenAlexW4377092202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.