Evidence map›Paper›PMID 37229494›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Unlocking cellular barriers: silica nanoparticles and fullerenol conjugated cell-penetrating agents for enhanced intracellular drug delivery.

Eduardo Ravelo-Nieto, Javier Cifuentes, Paola Ruiz Puentes, Laura Rueda-Gensini, Valentina Quezada, Carlos Ostos, Carolina Muñoz-Camargo, Luis H Reyes, Alvaro Duarte-Ruiz, Juan C Cruz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Effect of Fullerenol CNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Effect of Fullerenol CMolecules (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Eduardo Ravelo-NietoDepartment of Chemistry, Universidad Nacional de Colombia, Bogotá, Colombia.
Javier CifuentesDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Paola Ruiz PuentesDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Laura Rueda-GensiniDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Valentina QuezadaDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Carlos OstosGrupo CATALAD, Instituto de Química, Universidad de Antioquia, Medellín, Colombia.
Carolina Muñoz-CamargoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Luis H ReyesGrupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá, Colombia.
Alvaro Duarte-RuizDepartment of Chemistry, Universidad Nacional de Colombia, Bogotá, Colombia.
Juan C CruzDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombi.
Universidad de Los Andes · BOUniversidad de Los Andes · COUniversidad de Antioquia · COUniversidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The limited delivery of cargoes at the cellular level is a significant challenge for therapeutic strategies due to the presence of numerous biological barriers. By immobilizing the Buforin II (BUF-II) peptide and the OmpA protein on magnetite nanoparticles, a new family of cell-penetrating nanobioconjugates was developed in a previous study. We propose in this study to extend this strategy to silica nanoparticles (SNPs) and silanized fullerenol (F) as nanostructured supports for conjugating these potent cell-penetrating agents. The same molecule conjugated to distinct nanomaterials may interact with subcellular compartments differently. On the obtained nanobioconjugates (OmpA-SNPs, BUF-II-PEG

Indexed as

Buforin IIcellular uptakeendosomal escapefullerenolnanobioconjugateOmpAsilica nanoparticles

Identifiers

PMID37229494
PMCPMC10203439
OpenAlexW4378347514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.