Evidence map›Paper›PMID 37229297›Full record

ArticleRespirology case reports2023

Pulmonary alveolar proteinosis after lung transplantation: Two case reports and literature review.

Shinichi Kawana, Kentaroh Miyoshi, Shin Tanaka, Seiichiro Sugimoto, Dai Shimizu, Kei Matsubara, Mikio Okazaki, Noboru Hattori, Shinichi Toyooka

Open access · goldAbstract readCase Reports
In one paragraph

Article in Respirology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. A toxicology study ofMolecular therapy. Methods & clinical development · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shinichi KawanaDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Kentaroh MiyoshiDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.ORCID https://orcid.org/0000-0003-1589-1216
Shin TanakaDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Seiichiro SugimotoDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Dai ShimizuDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Kei MatsubaraDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Mikio OkazakiDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Noboru HattoriDepartment of Molecular and Internal Medicine Hiroshima University, Graduate School of Biomedical and Health Sciences Hiroshima Japan.
Shinichi ToyookaDepartment of General Thoracic Surgery and Organ Transplant Center Okayama University Hospital Okayama Japan.
Okayama University Hospital · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary alveolar proteinosis (PAP) affecting transplanted lungs is not well recognized. Herein, we report two cases of PAP after lung transplantation (LTx). The first case was a 4-year-old boy with hereditary pulmonary fibrosis who underwent bilateral LTx and presented with respiratory distress on postoperative day (POD) 23. He was initially treated for acute rejection, died due to infection on POD 248, and was diagnosed with PAP at autopsy. The second case involved a 52-year-old man with idiopathic pulmonary fibrosis who underwent bilateral LTx. On POD 99, chest computed tomography revealed ground-glass opacities. Bronchoalveolar lavage and transbronchial biopsy led to a diagnosis of PAP. Follow-up with immunosuppression tapering resulted in clinical and radiological improvement. PAP after lung transplantation mimics common acute rejection; however, is potentially transient or resolved with tapering immunosuppression, as observed in the second case. Transplant physicians should be aware of this rare complication to avoid misconducting immunosuppressive management.

Indexed as

graft dysfunctionimmunosuppressionlung transplantationpulmonary alveolar proteinosis

Identifiers

PMID37229297
PMCPMC10203803
OpenAlexW4378084189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.