Evidence map›Paper›PMID 37228903›Full record

ArticleContemporary clinical trials communications2023

Comparing the unified protocol for transdiagnostic treatment of emotional disorders to prolonged exposure for the treatment of PTSD: Design of a non-inferiority randomized controlled trial.

W Lau, K Chisholm, M W Gallagher, K Felmingham, K Murray, A Pearce, N Doyle, S Alexander, H O'Brien, A Putica and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

W LauPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
K ChisholmPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
M W GallagherDepartment of Psychology, The University of Houston, TX, USA.
K FelminghamMelbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia.
K MurrayPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
A PearcePhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
N DoylePhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
S AlexanderPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
H O'BrienPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
A PuticaPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
J KhatriCanberra Health Services, Australian Capital Territory Government, Canberra, Australia.
P BockelmannPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
F HosseinyAtlas Institute for Veterans and Families, Ottawa, Canada.
A LibradoAtlas Institute for Veterans and Families, Ottawa, Canada.
M NotarianniAtlas Institute for Veterans and Families, Ottawa, Canada.
M L O'DonnellPhoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prolonged Exposure (PE), a trauma-focused therapy, is one of the most efficacious treatments available for PTSD. However, many people with PTSD do not lose their diagnosis following delivery of PE. The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders is a non-trauma focused treatment that may offer an alternative treatment for PTSD. Methods: This paper describes the study protocol for IMPACT, an assessor-blinded randomized controlled trial that examines the non-inferiority of UP relative to PE for participants who meet DSM-5 criteria for current PTSD. One hundred and twenty adult participants with PTSD will be randomized to receive either 10 × 90-min sessions of UP or PE with a trained provider. The primary outcome is severity of PTSD symptoms assessed by the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) at post-treatment. Discussion: While evidence-based treatments are available for PTSD, high levels of treatment dropout and non-response require new approaches to be tested. The UP is based on emotion regulation theory and is effective in treating anxiety and depressive disorders, however, there has been limited application to PTSD. This is the first rigorous study comparing UP to PE in a non-inferiority randomized controlled trial and may help improve clinical outcomes for those with PTSD. Trial registration: This trial was prospectively registered with the Australian New Zealand Clinical Trials Registry, Trial ID (ACTRN12619000543189).

Indexed as

Emotion regulationPosttraumatic stress disorderProlonged exposurePTSDRandomized controlled trialTransdiagnostic treatmentUnified protocol

Identifiers

PMID37228903
PMCPMC10205430

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.