Evidence map›Paper›PMID 37228805›Full record

ArticleInfluenza and other respiratory viruses2023

Clinical outcomes of COVID-19 treated with remdesivir across the continuum of care.

Christina G Rivera, Supavit Chesdachai, Evan W Draper, Richard F Arndt, Kristin C Mara, Maria Gonzalez Suarez, Raymund R Razonable

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Christina G RiveraDepartment of Pharmacy Mayo Clinic Rochester Minnesota USA.ORCID 0000-0002-8308-3264
Supavit ChesdachaiDivision of Public Health, Infectious Diseases, and Occupational Medicine Mayo Clinic Rochester Minnesota USA.
Evan W DraperDepartment of Pharmacy Mayo Clinic Rochester Minnesota USA.
Richard F ArndtDepartment of Pharmacy Mayo Clinic Health System Eau Claire Wisconsin USA.
Kristin C MaraDepartment of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA.
Maria Gonzalez SuarezDivision of Nephrology and Hypertension Mayo Clinic Rochester Minnesota USA.
Raymund R RazonableDivision of Public Health, Infectious Diseases, and Occupational Medicine Mayo Clinic Rochester Minnesota USA.
Mayo Clinic · USMayo Clinic Health System · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: During the early phase of the coronavirus disease 2019 (COVID-19), remdesivir was only approved for hospitalized patients. Our institution developed hospital-based, outpatient infusion centers for selected hospitalized patients with COVID-19 who had clinical improvement to allow for early dismissal. The outcomes of patients who transitioned to complete remdesivir in the outpatient setting were examined. Methods: Retrospective study of all hospitalized adult patients with COVID-19 who received at least one dose of remdesivir from November 6, 2020, to November 5, 2021, at one of the Mayo Clinic hospitals. Results: Among 3029 hospitalized patients who received treatment with remdesivir for COVID-19, the majority (89.5%) completed the recommended 5-day course. Among them, 2169 (80%) patients completed treatment during hospitalization, whereas 542 (20.0%) patients were dismissed to complete remdesivir in outpatient infusion centers. Patients who completed the treatment in the outpatient setting had lower odds of death within 28 days (aOR 0.14, 95% CI 0.06-0.32, Conclusions: This study describes the clinical outcomes of a strategy of transitioning remdesivir therapy from inpatient to outpatient among selected patients. Mortality was lower among patients who completed the 5-day course of remdesivir.

Indexed as

COVID-19Adenosine MonophosphateAdultAlanineAntiviral AgentsContinuity of Patient CareCOVID-19 Drug TreatmentHumansRetrospective StudiesSARS-CoV-2Adenosine MonophosphateAlanineAntiviral AgentsremdesivirCOVID‐19hospitalizationremdesivirSARS‐2‐CoV

Identifiers

PMID37228805
PMCPMC10205088
OpenAlexW4377085025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.