Evidence map›Paper›PMID 37228503›Full record

ArticleFrontiers in oncology2023

Uterine serous carcinoma: assessing association between genomics and patterns of metastasis.

Francesco Alessandrino, Nicole Goncalves, Sarah Wishnek Metalonis, Cibele Luna, Matthew M Mason, Jiangnan Lyu, Marilyn Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Francesco AlessandrinoDepartment of Radiology, University of Miami, Miami, FL, United States.
Nicole GoncalvesUniversity of Miami Miller School of Medicine, Miami, FL, United States.
Sarah Wishnek MetalonisDivision of Biostatistics, Department of Public Health Science, University of Miami, Miami, FL, United States.
Cibele LunaDepartment of Radiology, University of Miami, Miami, FL, United States.
Matthew M MasonUniversity of Miami Miller School of Medicine, Miami, FL, United States.
Jiangnan LyuDivision of Biostatistics, Department of Public Health Science, University of Miami, Miami, FL, United States.
Marilyn HuangDivision of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami, FL, United States.
University of Miami · USSylvester Comprehensive Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Uterine serous carcinoma (USC) is an aggressive subtype of endometrial carcinoma which has been increasing at alarming rates, particularly among Asian, Hispanic and Black women. USC has not been well characterized in terms of mutational status, pattern of metastases and survival. Objective: To investigate the association between sites of recurrence and metastases of USC, mutational status, race, and overall survival (OS). Methods: This single-center retrospective study evaluated patients with biopsy-proven USC that underwent genomic testing between January 2015 and July 2021. Association between genomic profile and sites of metastases or recurrence was performed using χ2 or Fisher's exact test. Survival curves for ethnicity and race, mutations, sites of metastasis/recurrence were estimated using the Kaplan-Meier method and compared with log-rank test. Cox proportional hazard regression models were used to examine the association between OS with age, race, ethnicity, mutational status, and sites of metastasis/recurrence. Statistical analyses were performed using SAS Software Version 9.4. Results: The study included 67 women (mean age 65.8 years, range 44-82) with 52 non-Hispanic women (78%) and 33 Black women (49%). The most common mutation was Conclusions:

Indexed as

endometrial cancermetastasesnext generation sequencingrecurrencesomatic mutationsuterine serous cancer

Identifiers

PMID37228503
PMCPMC10203475
OpenAlexW4375950585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.