Evidence map›Paper›PMID 37228355›Full record

ArticleExploratory research in clinical and social pharmacy2023

Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study.

Carolyn Jane Ledowsky, Janet Schloss, Amie Steel

Open access · goldAbstract readCase Reports
In one paragraph

Article in Exploratory research in clinical and social pharmacy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Folate in autism neurodevelopment.Frontiers in nutrition · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Children (Basel, Switzerland) · 2025
    Review
  10. Frontiers in nutrition · 2025
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carolyn Jane LedowskyEndeavour College of Natural Health, now at University of Technology Sydney, Faculty of Health, Australia.
Janet SchlossSouthern Cross University, Natural Centre for Naturopathic Medicine, Lismore, NSW, Australia.
Amie SteelUniversity of Technology Sydney, Faculty of Health, Australia.
University of Technology Sydney · AUSouthern Cross University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Over 48.5 million couples are reported with infertility worldwide. Health policy recommends folic acid in women of childbearing age, particularly in preconception and pregnancy which results in women purchasing over-the-counter prenatal multivitamins containing folic acid through pharmacies and other retail outlets. Emerging studies are investigating whether other forms of supplemental folate are more suitable, particularly for those with methylenetetrahydrofolate reductase ( Methods: Australian practitioners were invited to complete a retrospective case report form for patients that presented with unexplained infertility. This case report form documented the form and dose of folate that practitioners were prescribing to their infertility patient with MTHFR polymorphisms, together with their fertility history. Results: Six practitioners submitted case information for 12 patients with diagnosed infertility and Conclusion: This case series has highlighted clinical practices that vary from the recommendations by Australian policy. Further research is required to verify the clinical importance of variations in folate prescriptions for women with

Indexed as

5-MTHFFolateFolic acidInfertilityMTHFRPolymorphism

Identifiers

PMID37228355
PMCPMC10205484
OpenAlexW4378348981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.