ArticlePLoS computational biology2023
Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Causal evidence from invasive recordings reveals distributed acoustic feature encoding underlying categorical voice perception.NeuroImage · 2026Article
- Electrical signatures of divergent connectivity in the human subgenual cingulate cortex.medRxiv : the preprint server for health sciences · 2026Article
- A Systematic Characterization of Causal Interactions Between Human Visual Areas.bioRxiv : the preprint server for biology · 2026Article
- The human insula encodes somatotopic representation of motor execution with an effector-specific connectome map to primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The role of thalamic stereoEEG in epilepsy clinical practice.Brain : a journal of neurology · 2026Article
- A practical preprocessing pipeline for concurrent TMS-iEEG: Critical steps and methodological considerations.NeuroImage · 2026Article
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- A Practical Preprocessing Pipeline for Concurrent TMS-iEEG: Critical Steps and Methodological Considerations.bioRxiv : the preprint server for biology · 2025Article
- Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data.Journal of neuroscience methods · 2025Article
- Parameterization of intraoperative human microelectrode recordings: Linking action potential morphology to brain anatomy.bioRxiv : the preprint server for biology · 2025Article
- Parameterization of intraoperative human microelectrode recordings: Linking action potential morphology to brain anatomy.PLoS computational biology · 2025Article
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Considerations and procedures for acquiring EEG as part of multi-site studies for Rett syndrome and other genetic neurodevelopmental disorders.Frontiers in integrative neuroscience · 2025Article
- ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.bioRxiv : the preprint server for biology · 2024Article
- Signatures of Electrical Stimulation Driven Network Interactions in the Human Limbic System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Single-pulse electrical stimulation in the nervous system, often called cortico-cortical evoked potential (CCEP) measurement, is an important technique to understand how brain regions interact with one another. Voltages are measured from implanted electrodes in one brain area while stimulating another with brief current impulses separated by several seconds. Historically, researchers have tried to understand the significance of evoked voltage polyphasic deflections by visual inspection, but no general-purpose tool has emerged to understand their shapes or describe them mathematically. We describe and illustrate a new technique to parameterize brain stimulation data, where voltage response traces are projected into one another using a semi-normalized dot product. The length of timepoints from stimulation included in the dot product is varied to obtain a temporal profile of structural significance, and the peak of the profile uniquely identifies the duration of the response. Using linear kernel PCA, a canonical response shape is obtained over this duration, and then single-trial traces are parameterized as a projection of this canonical shape with a residual term. Such parameterization allows for dissimilar trace shapes from different brain areas to be directly compared by quantifying cross-projection magnitudes, response duration, canonical shape projection amplitudes, signal-to-noise ratios, explained variance, and statistical significance. Artifactual trials are automatically identified by outliers in sub-distributions of cross-projection magnitude, and rejected. This technique, which we call "Canonical Response Parameterization" (CRP) dramatically simplifies the study of CCEP shapes, and may also be applied in a wide range of other settings involving event-triggered data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.