Evidence map›Paper›PMID 37227845›Full record

ArticleNeuropsychology2023

The "when" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.

Gonzalo Forno, Mario A Parra, Daniela Thumala, Roque Villagra, Mauricio Cerda, Pedro Zitko, Agustín Ibañez, Patricia Lillo, Andrea Slachevsky

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Gonzalo FornoGeroscience Center for Brain Health and Metabolism.ORCID 0000-0003-2739-6028
Mario A ParraSchool of Psychological Sciences and Health, University of Strathclyde.ORCID 0000-0002-2412-648X
Daniela ThumalaGeroscience Center for Brain Health and Metabolism.ORCID 0000-0003-0392-7031
Roque VillagraGeroscience Center for Brain Health and Metabolism.
Mauricio CerdaIntegrative Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile.ORCID 0000-0003-3447-1815
Pedro ZitkoGeroscience Center for Brain Health and Metabolism.ORCID 0000-0003-1162-4591
Agustín IbañezLatin American Brain Health Institute, Universidad Adolfo Ibanez.ORCID 0000-0001-6758-5101
Patricia LilloGeroscience Center for Brain Health and Metabolism.ORCID 0000-0001-7398-7203
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism.ORCID 0000-0001-6285-3189
Center for Climate and Resilience Research · CLAdolfo Ibáñez University · CLMillennium Institute for Integrative Biology · CLUniversity of Strathclyde · GB

Funding

US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
Alzheimer's AssociationNIA NIH HHS R01 AG057234NIA NIH HHS R01 AG083799
6 · The paper itself

Abstract

objectiveCognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) have been recommended by the neurodegenerative disease working group as promising tests to aid in the early detection of AD. In this study, we investigated their complementary value across the clinical stages of the AD continuum.

methodOne hundred and seventeen older adults with subjective cognitive complaint (SCC), 79 with mild cognitive impairment (MCI), 31 patients with AD dementia (ADD), and 37 cognitively unimpaired (CU) subjects, underwent assessment with the VSTMBT and the picture version of the Spanish FCSRT.

resultsAfter controlling for multiple comparisons, significant differences were found across groups. The VSTMBT was the only test that "marginally" differentiated between CU and SCC (

conclusionsOur results suggest that the VSTMBT and the FCSRT are sensitive to the clinical continuum of AD. Whereas the former detects changes in the early prodromal stages, the latter is more sensitive to the advanced prodromal stages of AD. These novel tests can aid in the early detection, monitor disease progression and response to treatment, and thus support drug development programs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeurodegenerative DiseasesAgedHumansNeuropsychological TestsProdromal Symptoms

Identifiers

PMID37227845
PMCPMC10522796
OpenAlexW4378215611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.