Evidence map›Paper›PMID 37227817›Full record

ArticleCell reports2023

Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4

Hannah L Itell, Daryl Humes, Julie Overbaugh

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. CypA is a molecular barrier to HIV emergence from Eastern chimpanzees.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. HIV Virion Capturing Liposomes for Therapeutic Vaccination.bioRxiv : the preprint server for biology · 2025
    Article
  8. The Immunogenic Role of Self-DNA in T Cell Immunity.Clinical reviews in allergy & immunology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Interferon Epsilon: Properties and Functions.Current molecular medicine · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hannah L ItellMolecular and Cellular Biology PhD Program, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Daryl HumesDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Julie OverbaughDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: joverbau@fredhutch.org.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Innate immune determinants of HIV rebound and persistenceR01HD103571 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JULIE M. OVERBAUGH · 2020 to 2026
$6.7M
TOWARDS A MORE RELEVANT MODEL OF HIV INFECTIONDP1DA039543 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 2015 to 2019
$4.4M
Cell-intrinsic effectors of the antiviral interferon response against HIV in primary human samplesF31AI165168 · NIAID · FRED HUTCHINSON CANCER CENTER · PI ITELL, HANNAH · 2022 to 2023
$61k
NIAID NIH HHS F31 AI165168NICHD NIH HHS R01 HD103571NIDA NIH HHS DP1 DA039543NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Type I interferon (IFN) upregulates proteins that inhibit HIV within infected cells. Prior studies have identified IFN-stimulated genes (ISGs) that impede lab-adapted HIV in cell lines, yet the ISG(s) that mediate IFN restriction in HIV target cells, primary CD4

Indexed as

HIV-1HIV InfectionsHIV SeropositivityInterferon Type ICD4-Positive T-LymphocytesCell LineHumansInterferon Type Iantiviral geneCD4(+) T cellCP: ImmunologyCRISPR-Cas9CRISPR screenHIV-1interferon-stimulated generestriction factortype I interferon

Identifiers

PMID37227817
PMCPMC10592456
OpenAlexW4377691120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.