Evidence map›Paper›PMID 37227686›Full record

ArticleJournal of cardiovascular translational research2023

Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography.

Trevor Simard, Richard Jung, Pietro Di Santo, Kiran Sarathy, Kamran Majeed, Pouya Motazedian, Spencer Short, Shan Dhaliwal, Alisha Labinaz, Dhruv Sarma and 6 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Dipyridamole and vascular healing following stent implantation.Frontiers in cardiovascular medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 3 countries.

Trevor Simard *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Richard Jung *Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Pietro Di SantoDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Kiran SarathyDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Kamran MajeedDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Pouya MotazedianDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Spencer ShortDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Shan DhaliwalDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Alisha LabinazDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Dhruv SarmaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
F Daniel RamirezDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Michael FroeschlDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
Marino LabinazDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada.
David R HolmesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Mohamad AlkhouliDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Benjamin HibbertDivision of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada. bmhibbert@gmail.com.ORCID 0000-0003-0906-1363
University of Ottawa · CAMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1-2% annual rate of repeat revascularization-a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enabling complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and stent type in a rabbit model-important considerations for translational experimental design. Atherosclerosis leads to more prominent ISR proliferation independent of stent-related factors. The rabbit stent model mirrors clinical observations, while OCT-based virtual histology demonstrates utility for pre-clinical stent assessment. Pre-clinical models should incorporate clinical and stent factors as feasible to maximize translation to clinical practice.

Indexed as

Coronary Artery DiseaseCoronary RestenosisPercutaneous Coronary InterventionAnimalsCoronary AngiographyCoronary VesselsNeointimaRabbitsStentsTomography, Optical CoherenceTreatment OutcomeIn-stent restenosis (ISR)NeointimaOptical coherence tomography (OCT)Percutaneous coronary intervention (PCI)RabbitStentTranslational

Identifiers

PMID37227686
OpenAlexW4378172133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.