Evidence map›Paper›PMID 37227592›Full record

ArticleBasic research in cardiology2023

Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis.

Nadezhda Fefelova, Suwakon Wongjaikam, Sri Harika Pamarthi, Natthaphat Siri-Angkul, Thomas Comollo, Anshu Kumari, Vivek Garg, Andreas Ivessa, Siriporn C Chattipakorn, Nipon Chattipakorn and 2 more

Open access · greenAbstract read
In one paragraph

Article in Basic research in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  17. The role of mitochondria in iron overload-induced damage.Journal of translational medicine · 2024
    Review
  18. Potential Roles of IPBiomolecules · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nadezhda FefelovaDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Suwakon WongjaikamDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Sri Harika PamarthiDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Natthaphat Siri-AngkulDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Thomas ComolloDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Anshu KumariDepartment of Physiology, University of Maryland, Baltimore, MD, USA.
Vivek GargDepartment of Physiology, University of Maryland, Baltimore, MD, USA.
Andreas IvessaDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Siriporn C ChattipakornCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Nipon ChattipakornCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Judith K GwathmeyDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA.
Lai-Hua XieDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, 07103, USA. xiela@njms.rutgers.edu.ORCID http://orcid.org/0000-0003-2600-2269
Rutgers, The State University of New Jersey · USChiang Mai University · THUniversity of Maryland, Baltimore · US

Funding

Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
Ferroptosis in the Heart: Iron Calcium Crosstalk and CompartmentalizationR01HL157116 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI GWATHMEY, JUDITH K, XIE, LAI-HUA · 2022 to 2025
$2.4M
A population-based in silico platform for arrhythmia predictionR01HL134709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL157116
6 · The paper itself

Abstract

Iron overload associated cardiac dysfunction remains a significant clinical challenge whose underlying mechanism(s) have yet to be defined. We aim to evaluate the involvement of the mitochondrial Ca

Indexed as

Heart DiseasesIron OverloadAnimalsCalciumCalcium ChannelsIronMiceMyocytes, CardiacCalciumCalcium ChannelsIronmitochondrial calcium uniporterCardiac dysfunctionFerroptosisIron overload cardiac dysfunctionMitochondrial calcium uniporterMyocardial energeticsReactive oxygen species

Identifiers

PMID37227592
PMCPMC10589903
OpenAlexW4378173510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.