Evidence map›Paper›PMID 37227523›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

The power of telemedicine to improve CAR-T cell therapy programs: lessons learned from COVID-19 pandemic.

Filippo A Canale, Massimo Martino, Gaetana Porto, Chiara Verduci, Giuseppe Console, Giuseppe Irrera, Barbara Loteta, Virginia Naso, Marta Pugliese, Tiziana Moscato and 6 more

Open access · bronzeAbstract readCase ReportsReview
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Filippo A CanaleStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Massimo MartinoStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy. massimo.martino@ospedalerc.it.
Gaetana PortoStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Chiara VerduciStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Onco-Hematology Department, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", Presidio Morelli, Viale Europa, 89133, Reggio Calabria, Italy.
Giuseppe ConsoleStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Onco-Hematology Department, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", Presidio Morelli, Viale Europa, 89133, Reggio Calabria, Italy.
Giuseppe IrreraStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Onco-Hematology Department, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", Presidio Morelli, Viale Europa, 89133, Reggio Calabria, Italy.
Barbara LotetaStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Virginia NasoStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Marta PuglieseStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Tiziana MoscatoStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Stem Cell Program CIC 587, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", 89133, Reggio Calabria, Italy.
Anna FerreriStem Cell Transplantation and Cellular Therapies Unit "Alberto Neri", Onco-Hematology Department, Grande Ospedale Metropolitano, "Bianchi-Melacrino-Morelli", Presidio Morelli, Viale Europa, 89133, Reggio Calabria, Italy.
Davide NappiHematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy.
Fabio NicoliniImmunotherapy, Cell Therapy and Biobank (ITCB), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy.
Massimiliano MazzaImmunotherapy, Cell Therapy and Biobank (ITCB), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy.
Giovanni MartinelliScientific Directorate IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy.
Claudio CerchioneHematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy. claudio.cerchione@irst.emr.it.
Azienda ospedaliera "Bianchi-Melacrino-Morelli" · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCAR-T programs will burden increasingly on healthcare systems, since the implementation of these therapies involves: multidisciplinary team collaboration, post-infusion hospitalization with risk of life-threatening toxicities, frequent in hospital visits and prolonged follow-up which heavily influence patients' quality of life. In this review we propose an innovative, telehealth-based, model for monitoring CAR-T patients: this method was used for managing a case of COVID-19 infection occurred two weeks after CAR-T cell infusion.

methodsSeveral benefits for management of all these aspects of CAR-T programs could be made using telemedicine: for example, telemedicine real-time clinical monitoring could reduce the COVID-19 contagion risks for CAR-T patients.

resultsOur experience confirmed feasibility and utility of this approach in a real-life case. We believe that use of telemedicine for CAR-T patients could improve: the logistics of toxicity monitoring (frequent vital sign checks and neurologic assessments), the multidisciplinary team communication (patient selection, specialists consulting, coordination with pharmacists, etc.), the decrease in hospitalization time and the reduction of ambulatory visits.

conclusionsThis approach will be fundamental for future CAR-T cell program development, enhancing patients' quality of life and cost-effectiveness for healthcare systems.

Indexed as

COVID-19Receptors, Chimeric AntigenTelemedicineCell- and Tissue-Based TherapyHumansPandemicsQuality of LifeReceptors, Chimeric AntigenCAR-TCell therapyCOVID-19Health systemTelehealthTelemedicine

Identifiers

PMID37227523
PMCPMC10209549
OpenAlexW4378173554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.