Evidence map›Paper›PMID 37227343›Full record

ArticleJACC. Clinical electrophysiology2023

Lipomatous Metaplasia Facilitates Slow Conduction in Critical Ventricular Tachycardia Corridors Within Postinfarct Myocardium.

Lingyu Xu, Sohail Zahid, Mirmilad Khoshknab, Juwann Moss, Ronald D Berger, Jonathan Chrispin, David Callans, Francis E Marchlinski, Stefan L Zimmerman, Yuchi Han and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Role of Imaging in Ventricular Tachycardia Ablation.Diagnostics (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Reply to: Stochastic virtual heart model predictions.Nature cardiovascular research · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Lingyu XuCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: Lingyu.Xu@pennmedicine.upenn.edu.
Sohail ZahidDepartment of Internal Medicine, New York University Langone Medical Center, New York, New York, USA.
Mirmilad KhoshknabCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Juwann MossCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Ronald D BergerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Jonathan ChrispinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
David CallansCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Francis E MarchlinskiCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Stefan L ZimmermanDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Yuchi HanCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Benoit DesjardinsDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Natalia TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Saman NazarianCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: https://twitter.com/Dr_Nazarian_EP.
University of Pennsylvania · USJohns Hopkins University · USNYU Langone Health · USTwitter (United States) · US

Funding

Imaging-based Indentification of Premature Ventricular Contraction-mediatedR01HL148103 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HAN, YUCHI · 2020 to 2025
$2.8M
Implications of Intra-Myocardial Fat Deposition upon Propensity for Malignant ArrhythmiaR01HL142893 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN, TRAYANOVA, NATALIA A. · 2018 to 2021
$2.5M
NHLBI NIH HHS R01 HL142893NHLBI NIH HHS R01 HL148103
6 · The paper itself

Abstract

backgroundMyocardial lipomatous metaplasia (LM) has been reported to be associated with post-infarct ventricular tachycardia (VT) circuitry.

objectivesThis study examined the association of scar versus LM composition with impulse conduction velocity (CV) in putative VT corridors that traverse the infarct zone in post-infarct patients.

methodsThe cohort included 31 post-infarct patients from the prospective INFINITY (Intra-Myocardial Fat Deposition and Ventricular Tachycardia in Cardiomyopathy) study. Myocardial scar, border zone, and potential viable corridors were defined by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR), and LM was defined by computed tomography. Images were registered to electroanatomic maps, and the CV at each electroanatomic map point was calculated as the mean CV between that point and 5 adjacent points along the activation wave front.

resultsRegions with LM exhibited lower CV than scar (median = 11.9 vs 13.5 cm/s; P < 0.001). Of 94 corridors computed from LGE-CMR and electrophysiologically confirmed to participate in VT circuitry, 93 traversed through or near LM. These critical corridors displayed slower CV (median 8.8 [IQR: 5.9-15.7] cm/s vs 39.2 [IQR: 28.1-58.5]) cm/s; P < 0.001) than 115 noncritical corridors distant from LM. Additionally, critical corridors demonstrated low-peripheral, high-center (mountain shaped, 23.3%) or mean low-level (46.7%) CV patterns compared with 115 noncritical corridors distant from LM that displayed high-peripheral, low-center (valley shaped, 19.1%) or mean high-level (60.9%) CV patterns.

conclusionsThe association of myocardial LM with VT circuitry is at least partially mediated by slowing nearby corridor CV thus facilitating an excitable gap that enables circuit re-entry.

Indexed as

Myocardial InfarctionTachycardia, VentricularArrhythmias, CardiacCicatrixContrast MediaGadoliniumHumansMyocardiumProspective StudiesContrast MediaGadoliniumconduction velocityischemic cardiomyopathylipomatous metaplasiamyocardial infarctionventricular tachycardia

Identifiers

PMID37227343
PMCPMC11168467
OpenAlexW4377968525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.