Evidence map›Paper›PMID 37227047›Full record

ArticleBiopolymers2024

The basal and major pilins in the Corynebacterium diphtheriae SpaA pilus adopt similar structures that competitively react with the pilin polymerase.

Christopher K Sue, Nicole A Cheung, Brendan J Mahoney, Scott A McConnell, Jack M Scully, Janine Y Fu, Chungyu Chang, Hung Ton-That, Joseph A Loo, Robert T Clubb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biopolymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Christopher K SueDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8401-6581
Nicole A CheungUCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-1612-8952
Brendan J MahoneyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-4323-9276
Scott A McConnellDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-9997-5278
Jack M ScullyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0009-0006-1524-7884
Janine Y FuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8854-041X
Chungyu ChangMolecular Biology Institute, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6127-3086
Hung Ton-ThatMolecular Biology Institute, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-1611-0469
Joseph A LooDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-9989-1437
Robert T ClubbDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-5718-3985
University of California, Los Angeles · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Cell Surface Protein Anchoring in Gram-Positive BacteriaR01AI052217 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Thompson Clubb · 2002 to 2026
$8.5M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
UV Laser for Photodissociation-Mass Spectrometry of Proteins and Protein ComplexesR01GM103479 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A · 2012 to 2021
$3.2M
Advancing Mass Spectrometry Analyses of Proteins, Assemblies, and ProteoformsR35GM145286 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A Loo · 2022 to 2026
$1.9M
Bruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR SpectrometerS10OD016336 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLUBB, ROBERT THOMPSON · 2014 to 2014
$600k
NIAID NIH HHS R01 AI052217NIGMS NIH HHS R01 GM103479NIGMS NIH HHS R35 GM145286NIGMS NIH HHS T32 GM007185NIGMS NIH HHS T32 GM145388NIH HHS AI52217NIH HHS GM103479NIH HHS GM145286NIH HHS S10 OD016336NIH HHS T32GM007185NIH HHS T32GM145388
6 · The paper itself

Abstract

Many species of pathogenic gram-positive bacteria display covalently crosslinked protein polymers (called pili or fimbriae) that mediate microbial adhesion to host tissues. These structures are assembled by pilus-specific sortase enzymes that join the pilin components together via lysine-isopeptide bonds. The archetypal SpaA pilus from Corynebacterium diphtheriae is built by the

Indexed as

AminoacyltransferasesCorynebacterium diphtheriaeBacterial ProteinsCadmiumFimbriae ProteinsLysineAminoacyltransferasesBacterial ProteinsCadmiumFimbriae ProteinsLysinekineticsNMRpilussortasevirulence factors

Identifiers

PMID37227047
PMCPMC11164409
OpenAlexW4378172854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.