Evidence map›Paper›PMID 37226982›Full record

ArticleRevista espanola de salud publica2023

[Evolución de marcadores de laboratorio en pacientes con detección persistente de SARS-CoV-2.]

José María López-Pintor, Óscar Herráez Carrera, Javier Sánchez-López, Jorge Gaitán Pitera, María Huertas Vaquero, Antonio Tejera-Muñoz, Ángel Arias-Arias, María Ángeles Asencio Egea

Abstract readEnglish Abstract
In one paragraph

Article in Revista espanola de salud publica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José María López-PintorServicio de Microbiología, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.
Óscar Herráez CarreraServicio de Análisis Clínicos, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.
Javier Sánchez-LópezServicio de Microbiología, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.
Jorge Gaitán PiteraServicio de Microbiología, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.
María Huertas VaqueroServicio de Microbiología, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.
Antonio Tejera-MuñozUnidad de Investigación, Formación y Desarrollo (IDF), Hospital General La Mancha Centro. Madrid. España.
Ángel Arias-AriasUnidad de Investigación, Formación y Desarrollo (IDF), Hospital General La Mancha Centro. Madrid. España.
María Ángeles Asencio EgeaServicio de Microbiología, Hospital General La Mancha Centro. Alcázar de San Juan (Ciudad Real). España.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study of the evolution of certain biomarkers in patients with persistent detection of SARS-CoV-2 could determine the profile of the pathology that these patients may suffer. The objective of this study was to describe the evolution of different laboratory markers in patients with persistent detection of SARS-CoV-2, and determining these parameters were into reference values.

methodsPatients were divided into two groups: the control group (G0) included patients with a positive direct test for SARS-CoV-2 followed by 2 negative, while the problem group (G1) included patients with at least 3 consecutive positive tests. The time between consecutive samples was five to twenty days, and only patients with negative serology were included. Demographic data, comorbidities, symptoms, radiology and hospitalization were collected, as well as data from analytic and blood gases. The comparison between the study groups was realized using the t-student and U Mann-Whitney test for quantitative variables, and the χ2 test for qualitative variables. Results with p<0.05 were taken as significant.

resultsNinety patients were included, thirty-eight in G0 and fifty-two in G1. D-dimer decreased 10.20 times more in G0 patients, and normal levels of this parameter at t1 were 1.46 times more frequent in these patients. The percentage of lymphocytes increased sixteen times more in G0, and the normal values in t1 were 10.40 times more common in these patients. C-reactive protein decreased significantly in both groups, and lactate increased more in G1 patients.

conclusionsThe results of the study suggest that some biomarkers evolve differently in patients with persistent detection of SARS-CoV-2, which may have significant clinical impact. This information could help to determine the main organs or systems affected, allowing to anticipate socio-sanitary measures to prevent or compensate these alterations.

Indexed as

COVID-19Blood Gas AnalysisHumansLactic AcidSARS-CoV-2SpainLactic AcidBiomarkersLaboratory markersPersistenceSARS-CoV-2Spain

Identifiers

PMID37226982
PMCPMC10540886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.