Evidence map›Paper›PMID 37226857›Full record

ArticleBirth defects research2023

Early childhood outcomes of NICU graduates with cytomegalovirus infection in California.

Tatiana M Lanzieri, Tianyao Lu, Mihoko V Bennett, Susan R Hintz, David E Sugerman, Sheila C Dollard, Megan H Pesch, Maria A L Jocson, Henry C Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Tatiana M LanzieriDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-2499-4786
Tianyao LuCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, California, USA.
Mihoko V BennettCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, California, USA.
Susan R HintzCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, California, USA.
David E SugermanDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sheila C DollardDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Megan H PeschDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Maria A L JocsonCalifornia Children's Services (CCS), Department of Health Care Services, Integrated Systems of Care, Sacramento, California, USA.
Henry C LeeCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, California, USA.
Centers for Disease Control and Prevention · USStanford Health Care · USCalifornia Department of Health Care Services · USUniversity of California San Diego · USUniversity of Michigan · US

Funding

Congenital cytomegalovirus: Infant developmental trajectories and parent experiencesK23HD108278 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PESCH, MEGAN H. · 2022 to 2025
$678k
NICHD NIH HHS K23 HD108278
6 · The paper itself

Abstract

backgroundTo assess demographics and outcomes up to 3 years of age among children with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) during 2010-2021.

methodsThe California Perinatal Quality Care Collaborative (CPQCC) collects data on all very low birth weight (VLBW, birth weight ≤ 1500 g) and acutely ill infants with birth weight > 1500 g across 92% of NICUs in California. VLBW infants and those with neurological conditions are referred to a statewide high-risk infant follow-up (HRIF) program. CMV infection was defined as a positive culture or PCR identified during the NICU hospitalization.

resultsDuring 2010-2021, CMV reporting rates averaged 3.5/1000 VLBW infants (n = 205) and 1.1/1000 infants >1500 g (n = 128). Among all 333 infants with CMV, 314 (94%) were discharged home alive, 271 (86%) were referred for HRIF and 205 (65%) had ≥1 visit. Whereas infants born to mothers <20 years of age had highest CMV reporting rates and those born to Hispanic mothers comprised 49% of all infected infants, they had the highest loss of follow-up. At the 12-month visit (n = 152), 19 (13%) infants with CMV had bilateral blindness and 18 (12%) had hearing loss. At the 24-month visit, 5 (5%) of 103 had severe cerebral palsy.

conclusionsAmong infants admitted to the NICU, those with CMV diagnoses may over represent infants with more severe CMV disease and outcomes. The CPQCC and HRIF program findings may help inform implementation of surveillance for congenital CMV infection in other U.S. states and guide strategies to reduce disparities in access to services.

Indexed as

Cytomegalovirus InfectionsIntensive Care Units, NeonatalBirth WeightCaliforniaChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfant, Very Low Birth WeightPregnancycongenital infectioncytomegaloviruspremature infantprevalencevery low birth weight infant

Identifiers

PMID37226857
PMCPMC10316994
OpenAlexW4378173159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.