Evidence map›Paper›PMID 37226792›Full record

Trial reportCurrent medicinal chemistry2024

Efficacy of the Novel Formulation of Topical Liothyronine and Liothyronine-insulin in Mild to Moderate Diabetic Foot Ulcer: A Randomized, Triple-blind Clinical Trial.

Fatemeh Saghafi, Saeed Hossein Khalilzadeh, Vahid Ramezani, Fatemeh Pasandeh, Hossein Fallahzadeh, Adeleh Sahebnasagh

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatemeh SaghafiDepartment of Clinical Pharmacy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Saeed Hossein KhalilzadehDiabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Vahid RamezaniDepartment of Pharmaceutics, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Fatemeh PasandehPharmaceutical Sciences Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Hossein FallahzadehDepartments of Biostatistics and Epidemiology, Center for Healthcare Data Modeling, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Adeleh SahebnasaghDepartment of Internal Medicine, Clinical Research Center, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Funding

Research and Technology Department of Shahid Sadoughi University of Medical Sciences 6856
6 · The paper itself

Abstract

backgroundDiabetic foot ulcer (DFU) is one of the challenging complications of chronic diabetes.

objectiveThe study aimed to investigate whether liothyronine (T3) and liothyronineinsulin (T3/Ins) topical preparations could significantly reduce the healing time of DFU.

methodsA prospective, randomized, placebo-controlled, patient-blinded clinical trial was conducted on patients with mild to moderate DFU, over a lesion area of no greater than 100 cm

resultsOf 147 patients with DFUs, 78 patients (26 per group) completed the study and were included in the final evaluation. At the time of study termination, all participants in each of the T3 or T3/Ins groups were free of symptoms based on the REEDA score, while about 40% of participants in the control group were detected with each of grades 1, 2, or 3. A significant difference was observed on days 7, 14, and 21 of consumption of topical preparations (p-value < 0.001). The mean time to complete wound closure in the routine care group was about 60.6 days, while it was 15.9 and 16.4 days in T3 and T3/Ins groups, respectively. Within the T3 and T3/Ins groups, significant earlier wound closure was detected at day 28 (p-value < 0.001).

conclusionT3 or T3/Ins topical preparations are effective for wound healing and acceleration of wound closure in mild to moderate DFUs.

Indexed as

Administration, TopicalDiabetic FootInsulinWound HealingAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeInsulinclinical trialdiabetic foot ulcerliothyronineliothyronine-insulinmetabolic.Topical formulation

Identifiers

PMID37226792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.