Evidence map›Paper›PMID 37226515›Full record

ArticleCardiology in the young2024

Risk Factors for Adverse Outcomes in Term Infants with CHD and Definitive Necrotising Enterocolitis.

Anna M Deitch, Katie Moynihan, Robert Przybylski, Kimberlee Gauvreau, Nancy J Braudis, Bethany Farr, Biren Modi, Kimberly I Mills, Meena Nathan, Philip T Levy

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology in the young, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anna M DeitchDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Katie MoynihanDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Robert PrzybylskiDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kimberlee GauvreauDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Nancy J BraudisDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Bethany FarrDepartment of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Biren ModiDepartment of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kimberly I MillsDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Meena NathanDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-0186-1382
Philip T LevyDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5103-5834
Boston Children's Hospital · US

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
NHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

objectivesTo define the incidence of definitive necrotising enterocolitis in term infants with CHD and identify risk factors for morbidity/mortality.

methodsWe performed a 20-year (2000-2020) single-institution retrospective cohort study of term infants with CHD admitted to the Boston Children's Hospital cardiac ICU with necrotising enterocolitis (Bell's stage ≥ II). The primary outcome was a composite of in-hospital mortality and post-necrotising enterocolitis morbidity (need for extracorporeal membrane oxygenation, multisystem organ failure based on the paediatric sequential organ failure assessment score, and/or need for acute gastrointestinal intervention). Predictors included patient characteristics, cardiac diagnosis/interventions, feeding regimen, and severity measures.

resultsOf 3933 term infants with CHD, 2.1% (n = 82) developed necrotising enterocolitis, with 67% diagnosed post-cardiac intervention. Thirty (37%) met criteria for the primary outcome. In-hospital mortality occurred in 14 infants (17%), of which nine (11%) deaths were attributable to necrotising enterocolitis. Independent predictors of the primary outcome included moderate to severe systolic ventricular dysfunction (odds ratio 13.4,confidence intervals 1.13-159) and central line infections pre-necrotising enterocolitis diagnosis (odds ratio 17.7, confidence intervals 3.21-97.0) and mechanical ventilation post-necrotising enterocolitis diagnosis (odds ratio 13.5, confidence intervals 3.34-54.4). Single ventricle, ductal dependency, and feeding related factors were not independently associated with the primary outcome.

conclusionsThe incidence of necrotising enterocolitis was 2.1% in term infants with CHD. Adverse outcomes occurred in greater than 30% of patients. Presence of systolic dysfunction and central line infections prior to diagnosis and need for mechanical ventilation after diagnosis of necrotising enterocolitis can inform risk triage and prognostic counseling for families.

Indexed as

Enterocolitis, NecrotizingFetal DiseasesChildFemaleHumansInfantInfant, NewbornInfant, PrematureRetrospective StudiesRisk Factorscongenital heart diseaseNecrotizing enterocolitis

Identifiers

PMID37226515
PMCPMC11827044
OpenAlexW4378173299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.