Evidence map›Paper›PMID 37226245›Full record

ReviewCardiovascular diabetology2023

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems.

Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yaël Nossent, Susana Novella and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 24 citations in OpenAlex.

  1. Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Review
  2. A Review ofFoods (Basel, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 7 countries.

Gaia Spinetti *Laboratory of Cardiovascular Pathophysiology and Regenerative Medicine, IRCCS MultiMedica, Milan, Italy. gaia.spinetti@multimedica.it.
Martina Mutoli *Laboratory of Cardiovascular Pathophysiology and Regenerative Medicine, IRCCS MultiMedica, Milan, Italy.
Simona GrecoMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Milan, Italy.
Federica RiccioLaboratory of Cardiovascular Pathophysiology and Regenerative Medicine, IRCCS MultiMedica, Milan, Italy.
Soumaya Ben-AichaNational Heart & Lung Institute, Imperial College London, London, UK.
Franziska KennewegInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Amela JusicHAYA Therapeutics SA, Lausanne, Switzerland.
David de Gonzalo-CalvoTranslational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
Anne Yaël NossentDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Susana NovellaDepartment of Physiology, University of Valencia - INCLIVA Biomedical Research Institute, Valencia, Spain.
Georgios KararigasDepartment of Physiology, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Thomas ThumInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
Costanza EmanueliNational Heart & Lung Institute, Imperial College London, London, UK.
Yvan DevauxCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Milan, Italy. fabio.martelli@grupposandonato.it.
Imperial College London · GBIRCCS Policlinico San Donato · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMedizinische Hochschule Hannover · DEINCLIVA Health Research Institute · ESInstituto de Salud Carlos III · ESLeiden University Medical Center · NLLuxembourg Institute of Health · LUMultiMedica · ITUniversity of Iceland · IS

Funding

British Heart Foundation RG/20/9/35101European Research Council 101054460
6 · The paper itself

Abstract

Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experience a state of chronic or intermittent hyperglycemia resulting in damage to the vasculature, leading to micro- and macro-vascular diseases. These conditions are associated with low-grade chronic inflammation and accelerated atherosclerosis. Several classes of leukocytes have been implicated in diabetic cardiovascular impairment. Although the molecular pathways through which diabetes elicits an inflammatory response have attracted significant attention, how they contribute to altering cardiovascular homeostasis is still incompletely understood. In this respect, non-coding RNAs (ncRNAs) are a still largely under-investigated class of transcripts that may play a fundamental role. This review article gathers the current knowledge on the function of ncRNAs in the crosstalk between immune and cardiovascular cells in the context of diabetic complications, highlighting the influence of biological sex in such mechanisms and exploring the potential role of ncRNAs as biomarkers and targets for treatments. The discussion closes by offering an overview of the ncRNAs involved in the increased cardiovascular risk suffered by patients with diabetes facing Sars-CoV-2 infection.

Indexed as

Cardiovascular DiseasesCardiovascular SystemCOVID-19Diabetes MellitusHumansSARS-CoV-2Cardiovascular diseasesDiabetesInflammationNon-coding RNAs

Identifiers

PMID37226245
PMCPMC10206598
OpenAlexW4378072002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.