Evidence map›Paper›PMID 37226153›Full record

ArticleBMC complementary medicine and therapies2023

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers.

Marwa A A Fayed, Riham O Bakr, Nermeen Yosri, Shaden A M Khalifa, Hesham R El-Seedi, Dalia I Hamdan, Mohamed S Refaey

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Unveiling the Pharmacological Potential ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Mangrove Against Invasive Snails:Plants (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Marwa A A Fayed *Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt. marwa.fayed@fop.usc.edu.eg.ORCID http://orcid.org/0000-0001-5609-7436
Riham O BakrDepartment of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Nermeen Yosri *Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt.
Shaden A M KhalifaDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91, Stockholm, Sweden.
Hesham R El-SeediInternational Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing, 210024, China.
Dalia I HamdanDepartment of Pharmacognosy and Natural Products, Faculty of Pharmacy, Menoufia University, Shebin El-Koom, 32511, Egypt.
Mohamed S RefaeyDepartment of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt.
University of Sadat City · EGBeni-Suef University · EGJiangsu University · CNMenoufia University · EGOctober University of Modern Sciences and Arts · EGStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer represents one of the biggest healthcare issues confronting humans and one of the big challenges for scientists in trials to dig into our nature for new remedies or to develop old ones with fewer side effects. Halophytes are widely distributed worldwide in areas of harsh conditions in dunes, and inland deserts, where, to cope with those conditions they synthesize important secondary metabolites highly valued in the medical field. Several Tamarix species are halophytic including T.nilotica which is native to Egypt, with a long history in its tradition, found in its papyri and in folk medicine to treat various ailments.

methodsLC-LTQ-MS-MS analysis and

resultsT.nilotica n-butanol fraction of the flowers was found to be rich in phenolic content, where, LC-LTQ-MS-MS allowed the tentative identification of thirty-nine metabolites, based on the exact mass, the observed spectra fragmentation patterns, and the literature data, varying between tannins, phenolic acids, and flavonoids.

conclusionOur study suggested that T.nilotica flowers' n-butanol fraction is representing a promising cytotoxic candidate against liver cell carcinoma having potential phytoconstituents with variable targets and signaling pathways.

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularLiver NeoplasmsTamaricaceae1-ButanolFlowersHumansMCF-7 Cells1-ButanolAntineoplastic Agents1H-NMRCytotoxicityHuh-7LC–LTQ–MS–MSMCF-7Tamarix nilotica flowers

Identifiers

PMID37226153
PMCPMC10207722
OpenAlexW4378172773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.