ArticleBMC plant biology2023
Diversity and correlation analysis of endophytes and metabolites of Panax quinquefolius L. in various tissues.
Article in BMC plant biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 31 citations in OpenAlex.
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- Diversity and correlation of endophytic microbiota and Shikonin accumulation in Arnebia Euchroma roots across geographical origins.Scientific reports · 2025Article
- Network pharmacological prediction of chemical constituents and endophyte metabolites of medicinal plant Shengli grass.Scientific reports · 2025Article
- Endophytic bacterial diversity of Vicatia thibetica collected from Xizang and the association with flavonoid accumulation.Microbial ecology · 2025Article
- Shaping of the core microbiome by ginsenosides in American ginseng across diverse habitats.Scientific reports · 2025Article
- The response of Panax ginseng root microbial communities and metabolites to nitrogen addition.BMC plant biology · 2025Article
- Diversity and correlation analysis of microbiomes and metabolites of Sphagnum palustre in various microhabitats.BMC plant biology · 2025Article
- Biochar-induced microbial and metabolic reprogramming enhances bioactive compound accumulation in Panax quinquefolius L.BMC plant biology · 2025Article
- Mechanism allowing biochar to aid in arbuscular mycorrhizal colonization in Panax quinquefolius L. roots and improve secondary metabolite production.Mycorrhiza · 2025Article
- Diversity and Correlation Analysis of Endophytes and Top Metabolites inMicroorganisms · 2025Article
- Study of the Correlation Between Endophyte Abundances and Metabolite Levels in Different Parts of the Tissue of Cultivated and WildMolecules (Basel, Switzerland) · 2025Article
- Integration of deep neural network modeling and LC-MS-based pseudo-targeted metabolomics to discriminate easily confused ginseng species.Journal of pharmaceutical analysis · 2025Article
- Metabolome-driven microbiome assembly determining the health of ginger crop (Zingiber officinale L. Roscoe) against rhizome rot.Microbiome · 2024Article
- Endophytic fungi of Panax sokpayensis produce bioactive ginsenoside Compound K in flask fermentation.Scientific reports · 2024Article
- Revealing Medicinal Constituents ofMolecules (Basel, Switzerland) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPanax quinquefolius L. (American ginseng) is widely used in medicine due to its wealth of diverse pharmacological effects. Endophytes colonize within P. quinquefolius in multiple tissue types. However, the relationship between endophytes and the production of their active ingredients in different parts of the plant is not clear.
resultsIn this study, the relationship of endophytic diversity and the metabolites produced in different plant tissues of P. quinquefolius were analyzed using metagenomic and metabolomic approaches. The results showed relatively similar endophyte composition in roots and fibrils, but obvious differences between endophyte populations in stems and leaves. Species abundance analysis showed that at the phylum level, the dominant bacterial phylum was Cyanobacteria for roots, fibrils, stems and leaves, Ascomycota forroots and fibrils roots, and Basidiomycota for stems and leaves. LC-MS/MS technology was used to quantitatively analyze the metabolites in different tissues of P. quinquefolius. A total of 398 metabolites and 294 differential metaboliteswere identified, mainly organic acids, sugars, amino acids, polyphenols, and saponins. Most of the differential metabolites were enriched in metabolic pathways such as phenylpropane biosynthesis, flavonoid biosynthesis, citric acid cycle, and amino acid biosynthesis. Correlation analysis showed a positive and negative correlation between the endophytes and the differential metabolites. Conexibacter significantly enriched in root and fibril was significantly positively correlated with saponin differential metabolites, while cyberlindnera significantly enriched in stem and leaf was significantly negatively correlated with differential metabolites (p < 0.05).
conclusionThe endophytic communities diversity were relatively similar in the roots and fibrils of P. quinquefolius, while there were greater differences between the stems and leaves. There was significant difference in metabolite content between different tissues of P. quinquefolius. Correlation analysis methods demonstrated a correlation between endophytes and differential metabolism.
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