ArticleNature2023
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers.
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191citing papers in PubMed
38.8field-weighted citation impact, top 1% of its field
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Who cites it
191 citing papers in PubMed, 240 citations in OpenAlex.
- Research on tissue-resident macrophages in the field of cancer research: a bibliometric analysis from 2004 to 2025.Cell adhesion & migration · 2026Review
- Host metadherin coordinates hepatic lipid metabolism and CD8Cell metabolism · 2026Article
- Comparative analysis of the cardiotoxicity induced by doxorubicin and epirubicin and exploratory investigations of clinical parameters indicating the cardiotoxicity in healthy dogs.The Journal of veterinary medical science · 2026Article
- The Growth and Trends in Cancer-Induced Cachexia Research: A Bibliometric and AI-Guided Visualization Analysis.Cancer reports (Hoboken, N.J.) · 2026Review
- Towards liquid biopsy-based analysis of antitumour immunity.Nature reviews. Clinical oncology · 2026Review
- Systemic health impact of cancer-associated extracellular vesicles and particles.Nature reviews. Cancer · 2026Review
- Integrated single-cell multiomics reveals neutrophil-driven immune-metabolic reprogramming of Kupffer cells via thrombospondin-1/CD36 after surgical stress.JCI insight · 2026Article
- Circadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy.Nature cell biology · 2026Article
- Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD-208 via Lysosomal Rerouting of CD63+ Compartments.Journal of extracellular vesicles · 2026Article
- Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium-Dependent ANXA2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Exosome-Mediated Systemic Signaling: Mechanisms, Disease Integration, and Translational Potential.Current issues in molecular biology · 2026Review
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Tumoral extracellular vesicles and particles reprogram interstitial macrophages in the lung to promote vascular permeability and metastasis.Nature cancer · 2026Article
- Targeting RAB27A-mediated small extracellular vesicle secretion via CRISPR-Cas9 negatively affects proliferation and metastasis in both in vitro and in vivo SCLC models.Cancer gene therapy · 2026Article
- Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.Nature communications · 2026Article
- Tissue derived extracellular vesicles advance from disease mechanisms to clinical application.Discover nano · 2026Review
- Noncoding SNP rs17728461 modulates lung cancer progression via interchromosomal regulation of RAB27A expression.Oncogene · 2026Article
- From steatosis to metastasis: microenvironmental reprogramming of the liver in metabolic dysfunction-associated steatotic liver disease.Clinical and molecular hepatology · 2026Review
- Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.Nature reviews. Immunology · 2026Review
- Rab27: Molecular switch of tumor exosome secretion (Review).International journal of molecular medicine · 2026Review
131 more citing papers are in PubMed but not listed here.
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Authors and funding
43 authors at 13 institutions in 4 countries.
Gang Wang *Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jianlong Li *Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Linda BojmarChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Haiyan ChenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Zhong LiDuke Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, USA.
Gabriel C TobiasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Mengying HuChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Edwin A HomanCardiovascular Research Institute and Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2923-9635
Serena LucottiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Fengbo ZhaoChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Valentina PosadaDepartments of Molecular Genetics, Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
Peter R OxleySamuel J. Wood Library, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6170-1220
Michele CioffiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Han Sang KimChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Huajuan WangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Pernille LauritzenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Nancy BoudreauChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Zhanjun ShiDepartment of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Christin E BurdDepartments of Molecular Genetics, Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
Jonathan H ZippinDepartment of Dermatology, Weill Cornell Medical College of Cornell University, New York, NY, USA.ORCID 0000-0002-5882-0189
James C LoCardiovascular Research Institute and Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-0244-1670
Geoffrey S PittCardiovascular Research Institute and Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-2246-0289
Jonathan HernandezHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Constantinos P ZambirinisHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-2740-3259
Michael A HollingsworthFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-5255-8888
Paul M GrandgenettFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Maneesh JainFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-2020-3687
Surinder K BatraFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-9470-9317
Dominick J DiMaioDepartment of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Jean L GremDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kelsey A KluteDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Tanya M TrippettDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-3371-1445
Doru PaulDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Jacqueline BrombergDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7957-9339
David KelsenGastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6139-438X
Vinagolu K RajasekharOrthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John H HealeyOrthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-0802-1186
Irina R MateiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
William R JarnaginHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. res2025@med.cornell.edu.ORCID 0000-0002-5417-5995
Haiying ZhangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. haz2005@med.cornell.edu.ORCID 0000-0002-7158-2373
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. dcl2001@med.cornell.edu.ORCID 0000-0003-0193-4131
Cornell University · USUniversity of Nebraska Medical Center · USMemorial Sloan Kettering Cancer Center · USThe Ohio State University · USCold Spring Harbor Laboratory · USDuke University · USLinköping University · SEMinistry of Education of the People's Republic of China · CNNanfang Hospital · CNNantong University · CNNational Institutes of Health · USRutgers, The State University of New Jersey · USYonsei University · KR
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI WANCAI YANG · 1985 to 2026
$132.3MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MSystemic regulation of metastasisR35CA232093 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYDEN, DAVID CHARLES · 2018 to 2024
$7.0MGenetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0MTumor-derived extracellular vesicles in the pre-metastatic niche.R01CA207983 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Yves A DeClerck · 2017 to 2026
$5.6MDevelopment and application of asymmetric-flow field-flow (AF4) technology in fractionation and characterization of exosome subpopulations and novel nanoveiscles in pancreatic cancer modelR01CA218513 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jacob Geri, DAVID CHARLES LYDEN · 2017 to 2026
$4.3MMechanisms of cAMP-dependent regulation of melanosome pHR01AR077664 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jonathan Hale Zippin · 2021 to 2026
$3.6MUrine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancerR01CA254036 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATRA, SURINDER K., BRAND, RANDALL · 2021 to 2025
$3.1MTargeting S1PR1/JAK2/STAT3 Signaling Axis in EMDRU54CA163117 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI DECLERCK, YVES A · 2011 to 2015
$2.7MOptimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6MMultidisciplinary Research Training in Cardiovascular DiseaseT32HL160520 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Geoffrey S Pitt, Jonathan W. Weinsaft · 2022 to 2026
$2.0MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA207983NCI NIH HHS R01 CA218513NCI NIH HHS R01 CA234614NCI NIH HHS R01 CA237213NCI NIH HHS R01 CA254036NCI NIH HHS R35 CA232093NCI NIH HHS R50 CA211462NCI NIH HHS U54 CA163117NHLBI NIH HHS T32 HL160520NIAID NIH HHS R01 AI107301NIAMS NIH HHS R01 AR077664NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK121072
Abstract
Cancer alters the function of multiple organs beyond those targeted by metastasis
Indexed as
Extracellular VesiclesFatty AcidsFatty LiverLiverPancreatic NeoplasmsAnimalsCytochrome P-450 Enzyme SystemHumansInflammationKupffer CellsLiver NeoplasmsMiceOxidative PhosphorylationPalmitic Acidrab27 GTP-Binding ProteinsTumor MicroenvironmentCytochrome P-450 Enzyme SystemFatty AcidsPalmitic AcidRAB27A protein, humanrab27 GTP-Binding ProteinsTumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.