Evidence map›Paper›PMID 37225984›Full record

ArticleNature2023

Walking naturally after spinal cord injury using a brain-spine interface.

Henri Lorach, Andrea Galvez, Valeria Spagnolo, Felix Martel, Serpil Karakas, Nadine Intering, Molywan Vat, Olivier Faivre, Cathal Harte, Salif Komi and 24 more

4 registry-linked trialsAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 271 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06243952 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation

TypeinterventionalSponsorEcole Polytechnique Fédérale de LausanneRan2024 to 2030Enrolled3ConditionsSpinal Cord Injuries, ParaplegiaArmsARC-BSI Lumbar system
NCT06939660 narecruitingnot on this mapstarted 2025, after this paper: background citation

Spatiotemporal Spinal Cord Stimulation Based on Implantable Brain-machine Interfaces and Exoskeletons for Spinal Cord Injury (BASEGO)

TypeinterventionalSponsorXuanwu Hospital, BeijingRan2025 to 2027Enrolled3ConditionsSpinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury CervicalArmsBCI-SCS-EXS
NCT07610850 narecruitingnot on this mapstarted 2026, after this paper: background citation

Brain-controlled Spinal Cord Stimulation in Participants With Chronic Stroke for Lower and Upper Limb Rehabilitation

TypeinterventionalSponsorEcole Polytechnique Fédérale de LausanneRan2026 to 2032Enrolled3ConditionsStroke, HemiplegiaArmsARC-BSI Stroke system
NCT07744659 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Spinal Cord Stimulation for Poststroke Spasticity: a Multicentre, Double-blind, Randomised, Sham-controlled Trial (SCS-PSS)

TypeinterventionalSponsorBeijing Pins Medical Co., LtdRan2026 to 2027Enrolled92ConditionsSpasticity Post StrokeArmsActive spinal cord stimulation, Sham spinal cord stimulation
3 · Its place in the literature

Who cites it

271 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  9. In conversation with Grégoire Courtine.Nature neuroscience · 2026
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  13. [Analysis of the constraints of inherent limitations on the capability boundaries of brain-computer interfaces and corresponding strategies].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  14. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
    Review
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211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Henri Lorach *NeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Andrea Galvez *NeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Valeria SpagnoloNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Felix MartelUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.ORCID 0000-0003-4877-1771
Serpil KarakasUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.
Nadine InteringNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID 0000-0003-1741-2178
Molywan VatNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Olivier FaivreUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.
Cathal HarteNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Salif KomiNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Jimmy RavierNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Thibault CollinNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Laure CoquozNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Icare SakrNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Edeny BaakliniNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Sergio Daniel Hernandez-CharpakNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID 0000-0003-0477-8138
Gregory DumontNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Rik BuschmanMedtronic, Minneapolis, MN, USA.
Nicholas BuseMedtronic, Minneapolis, MN, USA.
Tim DenisonMedtronic, Minneapolis, MN, USA.
Ilse van NesDepartment of Rehabilitation, Sint Maartenskliniek, Nijmegen, the Netherlands.
Leonie AsbothNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Anne WatrinONWARD Medical, Lausanne, Switzerland.
Lucas StruberUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.ORCID 0000-0002-3890-9100
Fabien Sauter-StaraceUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.
Lilia LangarUniv. Grenoble Alpes, CHU Grenoble Alpes, Clinatec, Grenoble, France.
Vincent AuboirouxUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.ORCID 0000-0002-6385-3233
Stefano CardaDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Stephan ChabardesUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.
Tetiana AksenovaUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France.ORCID 0000-0003-4007-2343
Robin DemesmaekerNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID 0000-0003-0856-0929
Guillaume CharvetUniv. Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France. guillaume.charvet@cea.fr.ORCID 0000-0003-4938-9419
Jocelyne BlochNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. jocelyne.bloch@chuv.ch.ORCID 0000-0002-6405-1590
Grégoire CourtineNeuroX Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. gregoire.courtine@epfl.ch.ORCID 0000-0002-5744-4142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis

Indexed as

BrainBrain-Computer InterfacesElectric Stimulation TherapyNeurological RehabilitationSpinal CordSpinal Cord InjuriesWalkingHumansLegMaleQuadriplegiaReproducibility of Results

Identifiers

PMID37225984
PMCPMC10232367

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.