Evidence map›Paper›PMID 37225983›Full record

ArticleNature2023

A median fin derived from the lateral plate mesoderm and the origin of paired fins.

Keh-Weei Tzung, Robert L Lalonde, Karin D Prummel, Harsha Mahabaleshwar, Hannah R Moran, Jan Stundl, Amanda N Cass, Yao Le, Robert Lea, Karel Dorey and 13 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Lineage labeling with zebrafishbioRxiv : the preprint server for biology · 2024
    Article
  10. wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Keh-Weei TzungInstitute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.
Robert L LalondeDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-1803-0983
Karin D PrummelDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-6077-6407
Harsha MahabaleshwarLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0009-0000-7482-5791
Hannah R MoranDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-8056-5762
Jan StundlDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-3740-3378
Amanda N CassBiology Department, Wesleyan University, Middletown, CT, USA.ORCID 0000-0002-8998-9294
Yao LeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-2935-2993
Robert LeaDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Karel DoreyDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0003-0846-5286
Monika J TomeckaInstitute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.
Changqing ZhangLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Eline C BrombacherDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
William T WhiteCSIRO National Research Collections Australia, Australia National Fish Collection, Hobart, Tasmania, Australia.ORCID 0000-0001-9705-2453
Henry H RoehlSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0001-6497-2405
Frank J TulenkoAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
Christoph WinklerDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-4688-6241
Peter D CurrieAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-8874-8862
Enrique AmayaDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-1805-8548
Marcus C DavisDepartment of Physical and Biological Sciences, Western New England University, Springfield, MA, USA.ORCID 0000-0002-2462-0138
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Christian MosimannDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. christian.mosimann@cuanschutz.edu.ORCID 0000-0002-0749-2576
Tom J CarneyInstitute of Molecular and Cell Biology, A*STAR, Singapore, Singapore. tcarney@ntu.edu.sg.ORCID 0000-0003-2371-1924

Funding

Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
Mechanisms of human appendicular and cardiovascular comorbidities: An analysis of heterogeneity and lineage trajectories of the lateral plate mesodermK99HL168148 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LALONDE, ROBERT L · 2023 to 2024
$199k
Defining the developmental mechanisms of pericardium formationF31HL167580 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MORAN, HANNAH ROSE · 2023 to 2024
$65k
NHLBI NIH HHS F31 HL167580NHLBI NIH HHS K99 HL168148NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins invokes derivation from unpaired median fins via a pair of lateral fin folds located between pectoral and pelvic fin territories

Indexed as

Animal FinsBiological EvolutionMesodermZebrafishAnimalsBone Morphogenetic ProteinsLarvaBone Morphogenetic Proteins

Identifiers

PMID37225983
PMCPMC10266977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.