ArticleCellular and molecular life sciences : CMLS2023
The summating potential polarity encodes the ear health condition.
Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- CRISPR-free RNA base editing mediated PTC-readthrough restores hearing in mice with Otof nonsense mutation.Nature communications · 2025Article
- Changing Knowledge, Principles, and Technology in Contemporary Clinical Audiological Practice: A Narrative Review.Journal of clinical medicine · 2024Review
- The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent.Pflugers Archiv : European journal of physiology · 2024Article
- Signal processing and stimulation potential within the ascending auditory pathway: a review.Frontiers in neuroscience · 2023Review
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Abstract
The summating potential (SP), the DC potential which, along with the AC response, is produced when the hair cells convert the vibrational mechanical energy of sound into electrical signals, is the most enigmatic of the cochlear potentials because its polarity and function have remained elusive for more than seven decades. Despite the tremendous socioeconomic consequences of noise-induced hearing loss and the profound physiological importance of understanding how loud noise exposure impairs the hair cell receptor activation, the relationship between the SP and noise-induced hearing impairment remains poorly characterized. Here, I show that in normally hearing ears, the SP polarity is positive and its amplitude relative to the AC response grows exponentially across frequencies, and becomes negative and decreases exponentially across frequencies following noise-induced hearing injury. Since the SP is thought to be generated by K
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