Evidence map›Paper›PMID 37225706›Full record

ArticleNature communications2023

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion.

Tabea M Eser, Olga Baranov, Manuel Huth, Mohammed I M Ahmed, Flora Deák, Kathrin Held, Luming Lin, Kami Pekayvaz, Alexander Leunig, Leo Nicolai and 17 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Tabea M EserDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Olga BaranovDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Manuel HuthInstitute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Mohammed I M AhmedDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Flora DeákDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Kathrin HeldDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.ORCID 0000-0001-7057-6935
Luming LinDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Kami PekayvazDepartment of Medicine I, University Hospital, LMU Munich, 81377, Munich, Germany.ORCID 0000-0003-4040-650X
Alexander LeunigDepartment of Medicine I, University Hospital, LMU Munich, 81377, Munich, Germany.ORCID 0000-0002-9179-9203
Leo NicolaiDepartment of Medicine I, University Hospital, LMU Munich, 81377, Munich, Germany.ORCID 0000-0003-0776-5885
Georgios PollakisInstitute of Infection and Global Health, University of Liverpool, Liverpool, L69 2BE, UK.ORCID 0000-0002-9659-5461
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden.ORCID 0000-0003-0633-1719
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, University Hospital, Heath Park, Cardiff, CF14 4XN, UK.ORCID 0000-0001-9416-2737
Raquel Rubio-AceroDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Jakob ReichDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Philine FalkDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Alissa MarkgrafDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Kerstin PuchingerDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Noemi CastellettiDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Laura OlbrichDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Kanika VanshyllaLaboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Florian KleinLaboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.ORCID 0000-0003-1376-1792
Andreas WieserDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Jan HasenauerInstitute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.ORCID 0000-0002-4935-3312
Inge KroidlDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Michael HoelscherDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
Christof GeldmacherDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany. geldmacher@lrz.uni-muenchen.de.
LMU Klinikum · DEUniversity of Cologne · DEHelmholtz Zentrum München · DEKarolinska University Hospital · SEUniversity Hospital of Wales · GBUniversity of Bonn · DEUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis of nasopharyngeal and peripheral blood samples obtained during the acute phase of infection with SARS-CoV-2. We find that soluble and transcriptional markers of systemic inflammation peak during the first week after symptom onset and correlate directly with upper airways viral loads (UA-VLs), whereas the contemporaneous frequencies of circulating viral nucleocapsid (NC)-specific CD4

Indexed as

COVID-19SARS-CoV-2CD8-Positive T-LymphocytesHumansNucleocapsidSeroconversion

Identifiers

PMID37225706
PMCPMC10209201
OpenAlexW4378172777

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.