ArticleLight, science & applications2023
Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology.
Article in Light, science & applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- All-optical closed-loop control of human cardiomyocyte networks exploiting holographic optogenetics.Communications engineering · 2026Article
- Active devices and systems for closed-loop neuromodulation.Microsystems & nanoengineering · 2026Review
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Review
- High density laminar recordings reveal cell type and layer specific responses to infrared neural stimulation in the rat neocortex.Scientific reports · 2024Article
- Mid-Infrared Photoacoustic Stimulation of Neurons through Vibrational Excitation in Polydimethylsiloxane.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes.Neurophotonics · 2024Article
- Implantable photonic nano-modulators open perspectives for advanced optical interfaces with deep brain areas.Neurophotonics · 2024Article
- Concomitant Light-Reversible Magnetic Response in Multiferroic Oxide Heterostructures for Multiphysics Applications.ACS applied materials & interfaces · 2024Article
- Light-controlled soft bio-microrobot.Light, science & applications · 2024Article
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Multifunctional Fiber-Based Optoacoustic Emitter as a Bidirectional Brain Interface.Advanced healthcare materials · 2023Article
- Mapping whole brain effects of infrared neural stimulation with positron emission tomography.Imaging neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Controlling neuronal activity using implantable neural interfaces constitutes an important tool to understand and develop novel strategies against brain diseases. Infrared neurostimulation is a promising alternative to optogenetics for controlling the neuronal circuitry with high spatial resolution. However, bi-directional interfaces capable of simultaneously delivering infrared light and recording electrical signals from the brain with minimal inflammation have not yet been reported. Here, we have developed a soft fibre-based device using high-performance polymers which are >100-fold softer than conventional silica glass used in standard optical fibres. The developed implant is capable of stimulating the brain activity in localized cortical domains by delivering laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo from the motor cortex and hippocampus in acute and chronic settings, respectively. Immunohistochemical analysis of the brain tissue indicated insignificant inflammatory response to the infrared pulses while the signal-to-noise ratio of recordings still remained high. Our neural interface constitutes a step forward in expanding infrared neurostimulation as a versatile approach for fundamental research and clinically translatable therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.