Evidence map›Paper›PMID 37225415›Full record

ArticleThorax2023

Acute respiratory failure-related excess mortality in pediatric sepsis.

Garrett Keim, Andrew G Percy, Adam S Himebauch, Jesse Y Hsu, Jason D Christie, Nadir Yehya

Open access · bronzeAbstract read
In one paragraph

Article in Thorax, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Clinical relevance of lung microbiota composition in critically ill children with acute lower respiratory tract infections: insights from a retrospective analysis of metagenomic sequencing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Garrett KeimDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA keimg@chop.edu.ORCID 0000-0002-7054-8798
Andrew G PercyDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Adam S HimebauchDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Jesse Y HsuCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jason D ChristieDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Nadir YehyaDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Pediatric Hospital Epidemiology and Outcomes Research Training ProgramT32HD060550 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Peter Bonafide, John Chris Feudtner · 2010 to 2026
$6.8M
Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)T32GM112596 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Roderic G Eckenhoff, Max Kelz · 2015 to 2026
$3.4M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
The Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress SyndromeK23HL153759 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI HIMEBAUCH, ADAM S. · 2021 to 2025
$879k
NHLBI NIH HHS K23 HL153759NHLBI NIH HHS K24 HL115354NICHD NIH HHS T32 HD060550NIGMS NIH HHS T32 GM112596
6 · The paper itself

Abstract

Excess mortality risk imparted by acute respiratory failure in children is unknown. We determined excess mortality risk associated with mechanically ventilated acute respiratory failure in pediatric sepsis. Novel ICD10-based algorithms were derived and validated to identify a surrogate for acute respiratory distress syndrome to calculate excess mortality risk. Algorithm-identified ARDS was identified with specificity of 96.7% (CI 93.0 - 98.9) and sensitivity of 70.5% (CI 44.0 - 89.7). Excess risk of mortality for ARDS was 24.4% (CI 22.9 - 26.2). Development of ARDS requiring mechanical ventilation imparts modest excess risk of mortality in septic children.

Indexed as

Respiratory Distress SyndromeRespiratory InsufficiencySepsisChildHospital MortalityHumansRespiration, ArtificialARDSCritical CarePaediatric Lung Disaese

Identifiers

PMID37225415
PMCPMC10953703
OpenAlexW4377970795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.