Evidence map›Paper›PMID 37225358›Full record

ArticleJournal of the American College of Cardiology2023

Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.

Hanyu Ni, Elizabeth Jordan, Daniel D Kinnamon, Jinwen Cao, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens and 22 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03037632 (Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03037632 naactive not recruitingnot on this map

Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry

TypeinterventionalSponsorRay HershbergerRan2016 to 2026Enrolled6,500ConditionsIdiopathic Dilated CardiomyopathyArmsFamily Heart Talk Booklet
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Diagnostic Tests for Stage B Heart Failure.Current cardiology reports · 2026
    Review
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Screening for dilated cardiomyopathy in immediate family members: to whom, how, when (and where).European heart journal supplements : journal of the European Society of Cardiology · 2024
    Article
  11. The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.American heart journal plus : cardiology research and practice · 2024
    Article
  12. The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.medRxiv : the preprint server for health sciences · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Hanyu NiDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Elizabeth JordanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Daniel D KinnamonDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jinwen CaoDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Garrie J HaasThe Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Mark HofmeyerMedstar Research Institute, Washington Hospital Center, Washington, DC, USA.
Evan KransdorfSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Gregory A EwaldWashington University, St Louis, Missouri, USA.
Alanna A MorrisEmory University School of Medicine, Atlanta, Georgia, USA.
Anjali OwensCenter for Inherited Cardiovascular Disease, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brian LowesUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Douglas StollerUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Sonia GargUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Barry H TrachtenbergHouston Methodist DeBakey Heart and Vascular Center, J.C. Walter Jr Transplant Center, Houston Texas, USA.
Palak ShahInova Heart and Vascular Institute, Falls Church, Virginia, USA.
Salpy V PamboukianUniversity of Alabama, Birmingham, Alabama, USA.
Nancy K SweitzerSarver Heart Center, University of Arizona, Tucson, Arizona, USA (current address Division of Cardiology, Washington University, St Louis, Missouri, USA).
Matthew T WheelerDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Jane E WilcoxNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Stuart KatzNew York University Langone Medical Center, New York, New York, USA.
Stephen PanDepartment of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, New York, USA.
Javier JimenezMiami Cardiac and Vascular Institute, Baptist Health South, Miami, Florida, USA.
Daniel P FishbeinUniversity of Washington, Seattle, Washington, USA.
Frank SmartLouisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Jessica WangUniversity of California Los Angeles Medical Center, Los Angeles, California, USA.
Stephen S GottliebUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Daniel P JudgeMedical University of South Carolina, Charleston, South Carolina, USA.
Charles K MooreUniversity of Mississippi Medical Center, Jackson, Mississippi, USA.
Gordon S HugginsCardiology Division, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA.
Ray E HershbergerDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address: Ray.Hershberger@osumc.edu.
DCM Precision Medicine Study of the DCM Consortium
The Ohio State University · USUniversity of Nebraska Medical Center · USAlaska Heart and Vascular Institute · USBaptist Hospital of Miami · USCedars-Sinai Medical Center · USCleveland Clinic · USEmory University · USHouston Methodist · USJackson Memorial Hospital · USLouisiana State University Health Sciences Center New Orleans · USMedical University of South Carolina · USMedStar Washington Hospital Center · USNorthwestern University · USNYU Langone Health · USStanford University · USThe University of Texas Southwestern Medical Center · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · USUniversity of California, Los Angeles · US

Funding

Precision Medicine for Dilated Cardiomyopathy in European and African AncestryR01HL128857 · NHLBI · OHIO STATE UNIVERSITY · PI HERSHBERGER, RAY E. · 2015 to 2020
$12.4M
Functional Validation of Myh14 in Stress-Induced Cardiac Remodeling.K08HL133491 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, JESSICA J · 2017 to 2021
$875k
NHLBI NIH HHS K08 HL133491NHLBI NIH HHS R01 HL128857
6 · The paper itself

Abstract

backgroundCardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD).

objectivesThis study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients.

methodsAdult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics results.

resultsA total of 1,365 FDRs were included, with a mean age of 44.8 ± 16.9 years, 27.5% non-Hispanic Black, 9.8% Hispanic, and 61.7% women. Among screened FDRs, 14.1% had new diagnoses of DCM (2.1%), LVSD (3.6%), or LVE (8.4%). The percentage of FDRs with new diagnoses was higher for those aged 45 to 64 years than 18 to 44 years. The age-adjusted percentage of any finding was higher among FDRs with hypertension and obesity but did not differ statistically by race and ethnicity (16.2% for Hispanic, 15.2% for non-Hispanic Black, and 13.1% for non-Hispanic White) or sex (14.6% for women and 12.8% for men). FDRs whose probands carried clinically reportable variants were more likely to be identified with DCM.

conclusionsCardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs.

Indexed as

Cardiomyopathy, DilatedAdultBlack PeopleEchocardiographyEthnicityFemaleHispanic or LatinoHumansHypertrophy, Left VentricularMaleMiddle Ageddilated cardiomyopathyfamily membersscreening

Identifiers

PMID37225358
PMCPMC10563038
OpenAlexW4377229948

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.