Evidence map›Paper›PMID 37225276›Full record

ArticleBMJ open2023

Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults.

James R Broatch, Navabeh Zarekookandeh, Rebecca Glarin, Myrte Strik, Leigh A Johnston, Bradford A Moffat, Laura J Bird, Kate Gunningham, Leonid Churilov, Hannah T Johns and 5 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

James R BroatchInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia james.broatch@vu.edu.au.ORCID 0000-0002-0082-3168
Navabeh ZarekookandehInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Rebecca GlarinMelbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.
Myrte StrikMelbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.
Leigh A JohnstonMelbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.
Bradford A MoffatMelbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.
Laura J BirdTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Kate GunninghamInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Leonid ChurilovMelbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Hannah T JohnsMelbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Christopher D AskewSunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Nambour, Queensland, Australia.
Itamar LevingerInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Shane F O'RiordanInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
David J BishopInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Amy BrodtmannCognitive Health Initiative, Central Clinical School, Monash University, Clayton, Victoria, Australia.
The University of Melbourne · AUVictoria University · AUThe Royal Melbourne Hospital · AUAustralian Institute for Musculoskeletal Science · AUMonash University · AUUniversity of the Sunshine Coast · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRegular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the association between greater cardiorespiratory fitness and larger brain volume, superior cognitive performance and lower dementia risk. However, the optimal aerobic exercise dose, namely the intensity and mode of delivery, to improve brain health and lower dementia risk has received less attention. We aim to determine the effect of different doses of aerobic exercise training on markers of brain health in sedentary middle-aged adults, hypothesising that high-intensity interval training (HIIT) will be more beneficial than moderate-intensity continuous training (MICT). METHODS AND ANALYSIS: In this two-group parallel, open-label blinded endpoint randomised trial, 70 sedentary middle-aged (45-65 years) adults will be randomly allocated to one of two 12-week aerobic exercise training interventions matched for total exercise training volume: (1) MICT (n=35) or HIIT (n=35). Participants will perform ~50 min exercise training sessions, 3 days per week, for 12 weeks. The primary outcome will be measured as between-group difference in cardiorespiratory fitness (peak oxygen uptake) change from baseline to the end of training. Secondary outcomes include between-group differences in cognitive function and ultra-high field MRI (7T) measured markers of brain health (brain blood flow, cerebrovascular function, brain volume, white matter microstructural integrity and resting state functional brain activity) changes from baseline to the end of training. ETHICS AND DISSEMINATION: The Victoria University Human Research Ethics Committee (VUHREC) has approved this study (HRE20178), and all protocol modifications will be communicated to the relevant parties (eg, VUHREC, trial registry). Findings from this study will be disseminated via peer-review publications, conference presentations, clinical communications and both mainstream and social media. TRIAL REGISTRATION NUMBER: ANZCTR12621000144819.

Indexed as

DementiaWhite MatterAdultBrainCognitionExerciseHumansMiddle AgedClinical trialsDementiaMagnetic resonance imagingSPORTS MEDICINE

Identifiers

PMID37225276
PMCPMC10230901
OpenAlexW4378173355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.