ArticleContemporary clinical trials2023
Equity and bias in electronic health records data.
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Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Spatial bias in quality of estimated delivery date records in the electronic health record.JAMIA open · 2026Article
- Nurses' Ethical Reasoning About Digital Ethical Risks: A Vignette-Elicited Qualitative Study.International nursing review · 2026Article
- AI-based multimodal integration of genomics and electronic health records.Nature reviews. Genetics · 2026Review
- Article
- Functional outcomes of children after SARS-CoV-2 infection: An EHR-based cohort study.Journal of pediatric rehabilitation medicine · 2026Article
- A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- From Scale to Situated: Sociotechnical Imaginaries and the Configuration of Algorithmic Health Research.Sociology of health & illness · 2026Article
- The potential, perils and pitfalls of Artificial intelligence (AI) in Assisted Reproductive Technologies (ART).Reproductive biology and endocrinology : RB&E · 2026Review
- Sex differences in cardiovascular disease and associated factors in people living with HIV: Evidence from All of Us program.HIV medicine · 2026Article
- Training the next-generation of biomedical scientists through artificial intelligence-driven education and research in pharmacology and pharmaceutical sciences.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Connecting biospecimens and data: a scoping review-informed conceptual framework for digital infrastructure in biobanking and genomic research in low- and middle-income countries.Frontiers in public health · 2026Article
- A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025Article
- Incompleteness of Electronic Health Records: An Impending Process Problem Within Healthcare.Healthcare (Basel, Switzerland) · 2025Article
- The Lifecycle of Electronic Health Record Data in HIV-Related Big Data Studies: Qualitative Study of Bias Instances and Potential Opportunities for Minimization.Journal of medical Internet research · 2025Article
- Collection of Patient-Reported Outcome Measures in Rural and Underserved Populations.Applied clinical informatics · 2025Article
- Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials.Contemporary clinical trials · 2025Article
- Evaluating EHR-Integrated Digital Technologies for Medication-Related Outcomes and Health Equity in Hospitalised Adults: A Scoping Review.Journal of medical systems · 2024Article
- On the evaluation of synthetic longitudinal electronic health records.BMC medical research methodology · 2024Article
- Recurring and Emerging Ethical Issues in Pragmatic Clinical Trials.Circulation. Cardiovascular quality and outcomes · 2024Article
- Inherent Bias in Electronic Health Records: A Scoping Review of Sources of Bias.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
23 authors.
Andrew D BoydDepartment of Biomedical and Health Information Sciences, University of Illinois Chicago, Chicago, IL, United States of America. Electronic address: boyda@uic.edu.
Rosa Gonzalez-GuardaDuke University School of Nursing, Durham, NC, United States of America.
Katharine LawrenceDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States of America.
Crystal L PatilUniversity of Illinois Chicago, College of Nursing, Chicago, IL, United States of America.
Miriam O EzenwaUniversity of Florida College of Nursing, Gainesville, FL, United States of America.
Emily C O'BrienDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States of America.
Hyung PaekYale University, New Haven, CT, United States of America.
Jordan M BraciszewskiHenry Ford Health, Detroit, MI, United States of America.
Oluwaseun AdeyemiNew York University Grossman School of Medicine, Ronald O. Perelman Department of Emergency Medicine, New York, NY, United States of America.
Allison M CuthelNew York University Grossman School of Medicine, Ronald O. Perelman Department of Emergency Medicine, New York, NY, United States of America.
Juanita E DarbyUniversity of Illinois Chicago, College of Nursing, Chicago, IL, United States of America.
Christina K ZiglerDuke University School of Medicine, Durham, NC, United States of America.
P Michael HoDivision of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Keturah R FaurotDepartment of Physical Medicine and Rehabilitation, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.
Karen StamanDuke University School of Medicine, Durham, NC, United States of America.
Jonathan W LeighUniversity of Illinois Chicago, College of Nursing, Chicago, IL, United States of America.
Dana L DaileySt. Ambrose University, Davenport, IA, United States of America; University of Iowa, Iowa City, IA, United States of America.
Andrea ChevilleMayo Clinic Comprehensive Cancer Center, Rochester, MN, United States of America.
Guilherme Del FiolDepartment of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Mitchell R KniselyDuke University School of Nursing, Durham, NC, United States of America.
Keith MarsoloDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States of America.
Rachel L RichessonDepartment of Learning Health Sciences, University of Michigan Medical School.
Judith M SchlaegerUniversity of Illinois Chicago, College of Nursing, Chicago, IL, United States of America.
Funding
NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)U24AT009676 · NCCIH · DUKE UNIVERSITY · PI LESLEY H CURTIS, Adrian Hernandez · 2017 to 2026
$21.5MPragmatic Trial of Acupuncture for Chronic Low Back Pain in Older AdultsUH3AT010739 · NCCIH · KAISER FOUNDATION RESEARCH INSTITUTE · PI COOK, ANDREA JEAN, DEBAR, LYNN L. · 2020 to 2022
$9.1MPrimary Palliative Care for Emergency MedicineUH3AT009844 · NCCIH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GOLDFELD, KEITH, GRUDZEN, CORITA R · 2019 to 2022
$7.9MGroup-Based Mindfulness for Patients with Chronic Low Back Pain in the Primary CareUH3AT010621 · NCCIH · BOSTON MEDICAL CENTER · PI MORONE, NATALIA E. · 2020 to 2023
$7.8MFibromyalgia TENS in Physical Therapy Study (TIPS): an embedded pragmatic clinical trial: Administrative SupplementUH3AR076387 · NIAMS · UNIVERSITY OF IOWA · PI CROFFORD, LESLIE J, SLUKA, KATHLEEN A · 2020 to 2023
$7.3MEMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use DisorderUH3DA047003 · NIDA · YALE UNIVERSITY · PI D'ONOFRIO, GAIL, MELNICK, EDWARD ROBERT · 2019 to 2022
$7.2MHEAL Collaboratory Resource Coordinating Center (PRISM) (U24): Bioethics SupplementU24AT010961 · NCCIH · DUKE UNIVERSITY · PI CURTIS, LESLEY H, HERNANDEZ, ADRIAN · 2019 to 2021
$6.4MHybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainUH3AT011265 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z, EZENWA, MIRIAM OMELEBELE · 2021 to 2024
$6.4MExtending the delivery of Guiding Good Choices to Spanish-speaking parents in primary care: Administrative supplement to the Guiding Good Choices for Health studyUH3AT009838 · NCCIH · UNIVERSITY OF WASHINGTON · PI KUKLINSKI, MARGARET, STERLING, STACY ANN · 2019 to 2022
$6.2MNon-pharmacological Options in postoperative Hospital-based And Rehabilitation pain Management (NOHARM) pragmatic clinical trialUH3AG067593 · NIA · MAYO CLINIC ROCHESTER · PI CHEVILLE, ANDREA LYNNE, TILBURT, JON C · 2020 to 2023
$6.0MPersonalized Patient data and behavioral nudges to improve adherence to chronic cardiovascular medicationsUH3HL144163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALLEN, LARRY ALEXANDER, BULL, SHEANA S · 2019 to 2022
$5.7MNonpharmacologic Pain Management in FQHC primary care clinicsUH3NR019943 · NINR · UNIVERSITY OF UTAH · PI FRITZ, JULIE M · 2021 to 2024
$4.9MNCCIH NIH HHS U24 AT009676NCCIH NIH HHS U24 AT010961NCCIH NIH HHS UG3 AT009838NCCIH NIH HHS UG3 AT009844NCCIH NIH HHS UG3 AT010621NCCIH NIH HHS UG3 AT010739NCCIH NIH HHS UG3 AT011265NCCIH NIH HHS UH3 AT009838NCCIH NIH HHS UH3 AT009844NCCIH NIH HHS UH3 AT010621NCCIH NIH HHS UH3 AT010739NCCIH NIH HHS UH3 AT011265NHLBI NIH HHS UG3 HL144163NHLBI NIH HHS UH3 HL144163NIAMS NIH HHS UG3 AR076387NIAMS NIH HHS UH3 AR076387NIA NIH HHS UG3 AG067593NIA NIH HHS UH3 AG067593NIDA NIH HHS UG3 DA047003NIDA NIH HHS UH3 DA047003NINR NIH HHS UG3 NR019943NINR NIH HHS UH3 NR019943
Abstract
Embedded pragmatic clinical trials (ePCTs) are conducted during routine clinical care and have the potential to increase knowledge about the effectiveness of interventions under real world conditions. However, many pragmatic trials rely on data from the electronic health record (EHR) data, which are subject to bias from incomplete data, poor data quality, lack of representation from people who are medically underserved, and implicit bias in EHR design. This commentary examines how the use of EHR data might exacerbate bias and potentially increase health inequities. We offer recommendations for how to increase generalizability of ePCT results and begin to mitigate bias to promote health equity.
Indexed as
Electronic Health RecordsHealth EquityBiasData AccuracyHealth PromotionHumansCommunity engagementHealth equityHealth literacyPatient-reported outcomesSocial determinants of health
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.