ArticleNeuroImage2023
Relative contributions of different neural sources to the EEG.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
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- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Inferring neural sources from electroencephalography: foundations and frontiers.Journal of neural engineering · 2026Review
- Biotechnical Multiscale Engineering of Scaffolds for Stem Cell and Organoid Research.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Predicting spiking activity from scalp EEG.Journal of neural engineering · 2025Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.bioRxiv : the preprint server for biology · 2025Article
- Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans.Research square · 2025Article
- Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- BlueRecording: A pipeline for the efficient calculation of extracellular recordings in large-scale neural circuit models.PLoS computational biology · 2025Article
- Review
- Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.Biological psychiatry global open science · 2025Article
- Contributions of action potentials to scalp EEG: Theory and biophysical simulations.PLoS computational biology · 2025Article
- Heterochronous laminar maturation in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dogma dictates that the EEG signal is generated by postsynaptic currents (PSCs) because there are an enormous number of synapses in the brain, and PSCs have relatively long durations. However, PSCs are not the only potential source of electric fields in the brain. Action potentials, afterpolarizations, and presynaptic activity can also generate electric fields. Experimentally it is exceedingly difficult to delineate the contributions of different sources because they are casually linked. However, using computational modeling, we can interrogate the relative contributions of different neural elements to the EEG. We used a library of neuron models with morphologically realistic axonal arbors to quantify the relative contributions of PSCs, action potentials, and presynaptic activity to the EEG signal. Consistent with prior assertions, PSCs were the largest contributor to the EEG, but action potentials and afterpolarizations can also make appreciable contributions. For a population of neurons generating simultaneous PSCs and action potentials, we found that the action potentials accounted for up to 20% of the source strength while PSCs accounted for the other 80% and presynaptic activity negligibly contributed. Additionally, L5 PCs generated the largest PSC and action potential signals indicating that they the dominant EEG signal generator. Further, action potentials and afterpolarizations were sufficient to generate physiological oscillations, indicating that they are valid source contributors to the EEG. The EEG emerges from a combination of multiple different source, and, while PSCs are the largest contributor, other sources are non-negligible and should be included in modeling, analysis and interpretation of the EEG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.