ReviewNeuroscience and biobehavioral reviews2023
Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging.
Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signalling.Nature ecology & evolution · 2026Article
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Field experimentation enhances translation for behavioral neuroscience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Ecological Realism Accelerates Epigenetic Aging in Mice.Aging cell · 2025Article
- Vocal communication is seasonal in social groups of wild, free-living house mice.Proceedings. Biological sciences · 2025Article
- Competitive social feedback amplifies the role of early life contingency in male mice.Science (New York, N.Y.) · 2025Article
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- How can ethology inform the neuroscience of fear, aggression and dominance?Nature reviews. Neuroscience · 2024Review
- The fortunes and misfortunes of social life across the life course: A new era of research from field, laboratory and comparative studies.Neuroscience and biobehavioral reviews · 2024Article
- Sex-specific competitive social feedback amplifies the role of early life contingency in male mice.bioRxiv : the preprint server for biology · 2024Article
- Genetically identical mice express alternative reproductive tactics depending on social conditions in the field.Proceedings. Biological sciences · 2024Article
- Fantastic beasts and how to study them: rethinking experimental animal behavior.The Journal of experimental biology · 2024Article
- A new era in quantification of animal social behaviors.Neuroscience and biobehavioral reviews · 2024Review
- Assessing immune phenotypes using simple proxy measures: promise and limitations.Discovery immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Social experiences are strongly associated with individuals' health, aging, and survival in many mammalian taxa, including humans. Despite their role as models of many other physiological and developmental bases of health and aging, biomedical model organisms (particularly lab mice) remain an underutilized tool in resolving outstanding questions regarding social determinants of health and aging, including causality, context-dependence, reversibility, and effective interventions. This status is largely due to the constraints of standard laboratory conditions on animals' social lives. Even when kept in social housing, lab animals rarely experience social and physical environments that approach the richness, variability, and complexity they have evolved to navigate and benefit from. Here we argue that studying biomedical model organisms outside under complex, semi-natural social environments ("re-wilding") allows researchers to capture the methodological benefits of both field studies of wild animals and laboratory studies of model organisms. We review recent efforts to re-wild mice and highlight discoveries that have only been made possible by researchers studying mice under complex, manipulable social environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.