Evidence map›Paper›PMID 37224678›Full record

ArticleEnvironment international2023

Outdoor air pollution and histologic composition of normal breast tissue.

Jennifer L Ish, Mustapha Abubakar, Shaoqi Fan, Rena R Jones, Nicole M Niehoff, Jill E Henry, Gretchen L Gierach, Alexandra J White

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  5. Breast Cancer Exposomics.Life (Basel, Switzerland) · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jennifer L IshEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA. Electronic address: jennifer.ish@nih.gov.
Mustapha AbubakarOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: mustapha.abubakar2@nih.gov.
Shaoqi FanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: shaoqi.fan@nih.gov.
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: rena.jones@nih.gov.
Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA. Electronic address: nicole.niehoff@gmail.com.
Jill E HenryBiospecimen Collection and Banking Core, Susan G. Komen Tissue Bank at the IU Simon Comprehensive Cancer Center, Indianapolis, IN, USA. Electronic address: jihenry@iu.edu.
Gretchen L GierachOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: gierachg@mail.nih.gov.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA. Electronic address: alexandra.white@nih.gov.
National Cancer Institute · USNational Institute of Environmental Health Sciences · USIndiana University Health · US

Funding

Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES103332
6 · The paper itself

Abstract

backgroundBiologic pathways underlying the association between outdoor air pollution and breast cancer risk are poorly understood. Breast tissue composition may reflect cumulative exposure to breast cancer risk factors and has been associated with breast cancer risk among patients with benign breast disease. Herein, we evaluated whether fine particulate matter (PM

methodsMachine-learning algorithms were applied to digitized hematoxylin and eosin-stained biopsies of normal breast tissue to quantify the epithelium, stroma, adipose and total tissue area from 3,977 individuals aged 18-75 years from a primarily Midwestern United States population who donated breast tissue samples to the Susan G. Komen Tissue Bank (2009-2019). Annual levels of PM

resultsHigher residential PM

conclusionsOur findings are consistent with a possible role of PM

Indexed as

Air PollutantsAir PollutionBreast NeoplasmsCross-Sectional StudiesEnvironmental ExposureFemaleHumansObesityParticulate MatterAir PollutantsParticulate MatterAir pollutionBreast cancerK-means clusteringParticulate matter

Identifiers

PMID37224678
PMCPMC10247451
OpenAlexW4377091991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.