ArticleThe Journal of infectious diseases2023
APOBEC3F Is a Mutational Driver of the Human Monkeypox Virus Identified in the 2022 Outbreak.
Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 45 citations in OpenAlex.
- Toward Precision Vaccinology for Mpox: Rational Antigen Design, Next-Generation Platforms, and Immune Correlates of Protection.Tropical medicine and infectious disease · 2026Review
- Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone.Nature medicine · 2026Article
- Preventing Disease Emergence Following Eradication: Application to Mpox.bioRxiv : the preprint server for biology · 2026Article
- Article
- MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing.Journal of virology · 2026Article
- Insights into Monkeypox Virus: Host Immunity, Viral Immune Evasion, Recent Advances in Vaccines, Therapeutic Development, and Future Perspectives.Microorganisms · 2026Review
- Human outbreak detection and best practice MPXV analysis and interpretation with squirrel.Virus evolution · 2026Article
- Lessons for medical countermeasure development from unforeseen outbreaks.Emerging microbes & infections · 2025Review
- First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo.Communications medicine · 2025Article
- Emergence of Clade Ib Monkeypox Virus-Current State of Evidence.Emerging infectious diseases · 2025Review
- [Profile of mpox cases identified during surveillance of the Kokolo health zone in Kinshasa (DRC) from August to November 2024].Medecine tropicale et sante internationale · 2025Article
- Clinical Predictors and Determinants of Mpox Complications in Hospitalized Patients: A Prospective Cohort Study from Burundi.Viruses · 2025Article
- APOBEC3-Related Editing and Non-Editing Determinants of HIV-1 and HTLV-1 Restriction.International journal of molecular sciences · 2025Review
- Evolutionary epidemiology of the monkeypox virus in Shandong Province during the post-global outbreak era.Frontiers in microbiology · 2025Article
- Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu.Virology journal · 2024Article
- Review
- 2024 Mpox outbreak: A rapidly evolving public health emergency of international concern: Introduction of an Updated Mpox Identify-Isolate-Inform (3I) Tool.One health (Amsterdam, Netherlands) · 2024Article
- Phylogeny of Seven Genomes of Monkeypox Virus - Anhui Province, China, 2023.China CDC weekly · 2024Article
- Review
- Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo.Nature medicine · 2024Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOn May 6, 2022, a powerful outbreak of monkeypox virus (MPXV) had been reported outside of Africa, with many continuing new cases being reported around the world. Analysis of mutations among the 2 different lineages present in the 2021 and 2022 outbreaks revealed the presence of G->A mutations occurring in the 5'GpA context, indicative of APOBEC3 cytidine deaminase activity.
methodsBy using a sensitive polymerase chain reaction (differential DNA denaturation PCR) method allowing differential amplification of AT-rich DNA, we analyzed the level of APOBEC3-induced MPXV editing in infected cells and in patients.
resultsWe demonstrate that G->A hypermutated MPXV genomes can be recovered experimentally from APOBEC3 transfection followed by MPXV infection. Here, among the 7 human APOBEC3 cytidine deaminases (A3A-A3C, A3DE, A3F-A3H), only APOBEC3F was capable of extensively deaminating cytidine residues in MPXV genomes. Hyperedited genomes were also recovered in ∼42% of analyzed patients. Moreover, we demonstrate that substantial repair of these mutations occurs. Upon selection, corrected G->A mutations escaping drift loss contribute to the MPXV evolution observed in the current epidemic.
conclusionsStochastic or transient overexpression of the APOBEC3F gene exposes the MPXV genome to a broad spectrum of mutations that may be modeling the mutational landscape after multiple cycles of viral replication.
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