ReviewSleep2023
Beyond the symptom: the biology of fatigue.
Open access · hybridAbstract readReview
In one paragraph
Review in Sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity.Molecular psychiatry · 2026Pooled it
- The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.Acta neurologica Belgica · 2025Pooled it
- Multidimensional sleep health and its association with fatigue among patients undergoing hemodialysis in China.Sleep & breathing = Schlaf & Atmung · 2026Article
- Article
- Poststroke Fatigue: An Overlooked Barrier to Functional Recovery.Journal of the American Heart Association · 2026Article
- Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Fatigue in migraine patients and its clinical correlates: a large-scale hospital-based study.The journal of headache and pain · 2026Article
- The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.Journal of neurology · 2026Article
- Fatigue relief is possible.Frontiers in integrative neuroscience · 2026Review
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Fatigue relief: the contribution of non-invasive neuromodulation (FAREviaNM).Frontiers in neuroscience · 2026Article
- In vivo Effects of Acute Inflammatory Responses on Dopaminergic Receptor Expression in Leukocytes and Marginal Effects of Hypoxia Pretreatment.Neuroimmunomodulation · 2026Article
- The prevalence and associated factors of perceived physical and mental fatigability among older adults in regional China.BMC geriatrics · 2025Article
- Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Physiology (Bethesda, Md.) · 2025Review
- Characterization of Muscle Fatigue Degree in Cyclical Movements Based on the High-Frequency Components of sEMG.Biomimetics (Basel, Switzerland) · 2025Article
- Insomnia symptom severity and dynamics of arousal-related symptoms across the day.Journal of sleep research · 2025Article
- The metabolic basis of cancer-related fatigue.Neuroscience and biobehavioral reviews · 2025Review
- Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy.Cancer medicine · 2025Article
- Characterization of the salivary microbiome in healthy individuals under fatigue status.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 20 institutions in 7 countries.
David M RaizenDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5935-0476
Janet MullingtonDepartment of Neurology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9156-9424
Christelle AnacletDepartment of Neurological Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Gerard ClarkeDepartment of Psychiatry and Neurobehavioural Science, and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Hugo CritchleyBrighton and Sussex Medical School Department of Neuroscience, University of Sussex, Brighton, UK.
Robert DantzerDepartment of Symptom Research, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-9399-6107
Ronald DavisDepartment of Biochemistry and Genetics, Stanford University, Palo Alto, CA, USA.
Kelly L DrewDepartment of Chemistry and Biochemistry, Institute of Arctic Biology, Center for Transformative Research in Metabolism, University of Alaska Fairbanks, Fairbanks, AK, USA.
Josh FesselDivision of Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Patrick M FullerDepartment of Neurological Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Erin M GibsonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Mary HarringtonDepartment of Psychology, Neuroscience Program, Smith College, Northampton, MA, USA.
W Ian LipkinCenter for Infection and Immunity, and Departments of Neurology and Pathology, Columbia University, New York City, NY, USA.ORCID 0000-0002-8768-9386
Elizabeth B KlermanDivision of Sleep Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7402-3171
Nancy KlimasDepartment of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, USA.
Anthony L KomaroffDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Walter KoroshetzNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Lauren KruppDepartment of Neurology, NYU Grossman School of Medicine, NYC, NY, USA.
Anna KuppuswamyUniversity College London, Queen Square Institute of Neurology, London, England.
Julie LasselinDepartment of Psychology, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-8323-0714
Laura D LewisCenter for Systems Neuroscience, Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Pierre J MagistrettiBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.
Heidi Y MatosNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5486-0773
Christine MiaskowskiDepartment of Physiological Nursing, School of Nursing, University of California, San Francisco, CA, USA.
Andrew H MillerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Avindra NathNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0927-5855
Maiken NedergaardDepartments of Neurology and Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA.
Mark R OppDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Marylyn D RitchieDepartment of Genetics, Institute for Biomedical Informatics, Penn Center for Precision Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dragana RoguljaDepartment of Neurobiology, Harvard University, Boston, MA, USA.
Asya RollsRappaport Institute for Medical Research, Technion, Israel Institute of Technology, Haifa, Israel.
John D SalamoneDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Clifford SaperDepartment of Neurology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5788-3014
Vicky WhittemoreNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3980-9451
Glenn WylieRocco Ortenzio Neuroimaging Center at Kessler Foundation, East Hanover, NJ, USA.
Jarred YoungerDepartment of Psychology, University of Alabama, Birmingham, Birmingham, AL, USA.
Phyllis C ZeeCenter for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
H Craig HellerDepartment of Biology, Stanford University and Sleep Research Society, Stanford, CA, USA.
National Institutes of Health · USHarvard University · USBrigham and Women's Hospital · USNeurological Surgery · USStanford University · USUniversity of Pennsylvania · USBoston University · USBrighton and Sussex Medical School · GBColumbia University · USEmory University · USKessler Foundation · USKing Abdullah University of Science and Technology · SANational Hospital for Neurology and Neurosurgery · GBNew York University · USNorthwestern University · USNova Southeastern University · USSleep Research Society · USSmith College · USStockholm University · SETechnion – Israel Institute of Technology · IL
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MNeuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7MSLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5MProject 5: Novel strategies to prevent opioid-induced hypoventilation during sleep and identification of underlying mechanismsP01HL149630 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAVID ANDREW WELLMAN · 2020 to 2026
$22.3MRenovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI KELLY L DREW · 2019 to 2026
$16.4MThe roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HADINE JOFFE · 2020 to 2026
$13.7MViral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6MProject 3 : Clinical correlates and diagnostics in ME/CFSU54AI138370 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2017 to 2022
$10.7MA Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's DiseaseU01NS114001 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VIDENOVIC, ALEKSANDAR · 2019 to 2021
$6.5MMolecular-Genetic Dissection of Subcortical Circuitry Regulating ArousalR01NS073613 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Patrick M Fuller · 2011 to 2026
$5.5MCircuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8MPathogenic mechanisms of Neuro-PASC in older adultsR01AG059291 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARNETHON, MERCEDES RENEE, KNUTSON, KRISTEN · 2019 to 2023
$4.7MNCCIH NIH HHS R01 AT011429NCCIH NIH HHS R01 AT011439NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA193522NCI NIH HHS R21 CA267135NHLBI NIH HHS P01 HL149630NHLBI NIH HHS R01 HL125379NHLBI NIH HHS R01 HL128538NHLBI NIH HHS R01 HL140580NHLBI NIH HHS R01 HL166205NIAID NIH HHS R01 AI139550NIAID NIH HHS U54 AI138370NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG026465NIA NIH HHS R01 AG059291NIA NIH HHS R01 AG068579NIA NIH HHS R01 AG070135NIA NIH HHS U54 AG062322NICHD NIH HHS R01 HD097786NICHD NIH HHS R01 HD107064NIDA NIH HHS R21 DA052861NIGMS NIH HHS P20 GM130443NIGMS NIH HHS P20GM130443NIGMS NIH HHS R15 GM126545NIMH NIH HHS R01 MH121350NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS073613NINDS NIH HHS R01 NS099055NINDS NIH HHS R01 NS103161NINDS NIH HHS R01 NS109529NINDS NIH HHS R01 NS114526NINDS NIH HHS R01 NS119597NINDS NIH HHS R01 NS122779NINDS NIH HHS R01 NS126610NINDS NIH HHS R21 NS130712NINDS NIH HHS RF1 NS110049NINDS NIH HHS U01 NS114001NINDS NIH HHS U19 NS128613Wellcome Trust 202346/Z/16/Z
Abstract
A workshop titled "Beyond the Symptom: The Biology of Fatigue" was held virtually September 27-28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.
Indexed as
FatigueMotivationBiologyHumans
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.