Evidence map›Paper›PMID 37224449›Full record

ArticleACS synthetic biology2023

Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology.

Abigail J Smith, Elise A Naudin, Caitlin L Edgell, Emily G Baker, Bram Mylemans, Laura FitzPatrick, Andrew Herman, Helen M Rice, David M Andrews, Natalie Tigue and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 5 countries.

Abigail J SmithSchool of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.
Elise A NaudinSchool of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.ORCID 0000-0002-1318-3366
Caitlin L EdgellSchool of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.
Emily G BakerSchool of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.ORCID 0000-0002-1593-5525
Bram MylemansSchool of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
Laura FitzPatrickBioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K.ORCID 0000-0002-4879-612X
Andrew HermanFlow Cytometry Facility, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, U.K.
Helen M RiceFlow Cytometry Facility, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, U.K.
David M AndrewsOncology R&D, AstraZeneca, Cambridge CB21 6GH, U.K.
Natalie TigueBioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K.ORCID 0000-0001-9916-0255
Derek N WoolfsonSchool of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.ORCID 0000-0002-0394-3202
Nigel J SaverySchool of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.ORCID 0000-0002-0803-4075
University of Bristol · GBAstraZeneca (Australia) · AUAstraZeneca (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1Biotechnology and Biological Sciences Research Council BB/S002820/1Biotechnology and Biological Sciences Research Council BB/V006231/1
6 · The paper itself

Abstract

Synthetic biology applications would benefit from protein modules of reduced complexity that function orthogonally to cellular components. As many subcellular processes depend on peptide-protein or protein-protein interactions,

Indexed as

Escherichia coliSynthetic BiologyAnimalsMammalsPeptidesProteinsPeptidesProteinscoiled coilin-cell library screeningprotein−protein interactionsrational peptide designsynthetic biology

Identifiers

PMID37224449
PMCPMC10278171
OpenAlexW4378070558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.