ArticleScience advances2023
Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Environment-dependent epistasis shapes adaptation to fluctuating resources.bioRxiv : the preprint server for biology · 2026Article
- Genomic perplexity and the evolution of context-dependent function.Molecular biology and evolution · 2026Article
- Natural genetic variation in calcium sensor genes as a novel resource for abiotic stress tolerance in crops.Frontiers in plant science · 2026Review
- FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration inbioRxiv : the preprint server for biology · 2025Article
- Using supervised machine-learning approaches to understand abiotic stress tolerance and design resilient crops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- A direct experimental test of Ohno's hypothesis.eLife · 2025Article
- Article
- Bioengineering hybrid artificial life.Frontiers in bioinformatics · 2025Review
- Data-driven discovery of the interplay between genetic and environmental factors in bacterial growth.Communications biology · 2024Article
- Understanding developmental system drift.Development (Cambridge, England) · 2024Review
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Patterns of Fitness and Gene Expression Epistasis Generated by Beneficial Mutations in the rho and rpoB Genes of Escherichia coli during High-Temperature Adaptation.Molecular biology and evolution · 2024Article
- The distribution of fitness effects during adaptive walks using a simple genetic network.PLoS genetics · 2024Article
- Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation.Nature communications · 2024Article
- Two Distinct Regulatory Systems Control Pulcherrimin Biosynthesis inbioRxiv : the preprint server for biology · 2024Article
- Mechanistic causes of sign epistasis and its applications.Frontiers in genetics · 2024Review
- Improving Genetic Association Studies with a Novel Methodology that Unveils the Hidden Complexity of All-Cause Heart Failure.medRxiv : the preprint server for health sciences · 2023Article
- Robustness and innovation in synthetic genotype networks.Nature communications · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis confounds our understanding of how mutations affect the expression patterns of gene regulatory networks, a challenge exacerbated by the dependence of epistasis on the environment. We used the toolkit of synthetic biology to systematically assay the effects of pairwise and triplet combinations of mutant genotypes on the expression pattern of a gene regulatory network expressed in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.