ArticleScience advances2023
Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low- and middle-income countries.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Prediction of Spontaneous Preterm Birth in the Second Trimester: Current Models, Limitations, and the Way Forward.Indian journal of pediatrics · 2026Review
- Immunological maladaptation preceding spontaneous preterm birth in human pregnancies.Nature communications · 2026Article
- Multiomics characterization of acute child illness and mortality in Africa and South Asia.Nature communications · 2026Article
- Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes.Journal of global health · 2026Article
- Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies.BMC medicine · 2026Article
- Prematurity and Multidimensional Risk Patterns in Adolescent and Adult Pregnancies: A Principal Component Analysis in an Eastern European Cohort.Children (Basel, Switzerland) · 2025Article
- Maternal lipidomic signatures of preterm and small-for-gestational-age newborn infants in low- and middle-income countries.Science advances · 2025Article
- Associations of neonatal birth outcomes with amino acids and acylcarnitines: an observational study of over 3.3 million newborns in China.BMC medicine · 2025Observational
- Data science and artificial intelligence for maternal, newborn and child health: scoping review and thematic analysis.BMC public health · 2025Article
- Development and validation of machine learning models for predicting bronchopulmonary dysplasia risk in preterm neonates based on antenatal determinants: a retrospective cohort study.BMC pediatrics · 2025Article
- Towards a new taxonomy of preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Mitigation of outcome conflation in predicting patient outcomes using electronic health records.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Application of Multiomics in Perinatology: A Metabolomics Integration-Focused Review.International journal of molecular sciences · 2025Review
- Effect of initiation of antiretroviral drugs for HIV prevention or treatment on the vaginal microbiome of pregnant women in Malawi.NPJ biofilms and microbiomes · 2025Article
- Advancing neonatal health: the promise and challenges of universal genome sequencing in newborn screening.Pediatric research · 2025Article
- A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment.Nature communications · 2025Article
- Generating pregnant patient biological profiles by deconvoluting clinical records with electronic health record foundation models.Briefings in bioinformatics · 2024Article
- Reassessing acquired neonatal intestinal diseases using unsupervised machine learning.Pediatric research · 2024Article
- Computational Approaches for Predicting Preterm Birth and Newborn Outcomes.Clinics in perinatology · 2024Review
- Predicting Spontaneous Preterm Birth Using the Immunome.Clinics in perinatology · 2024Review
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Authors and funding
57 authors at 9 institutions in 5 countries.
Camilo A EspinosaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1630-1564
Waqasuddin KhanDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0001-7995-8163
Rasheda KhanamDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-9365-8594
Sayan DasCentre for Public Health Kinetics, New Delhi, Delhi, India.ORCID 0000-0003-2948-6158
Javairia KhalidDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Jesmin PervinMaternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0002-8082-4178
Margaret P KasaroUniversity of North Carolina Global Projects Zambia, Lusaka, Zambia.ORCID 0000-0001-7285-998X
Kévin ContrepoisDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9678-5161
Alan L ChangDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1716-0134
Thanaphong PhongpreechaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9245-6686
Basil MichaelDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-4009-0912
Mathew EllenbergerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0965-9528
Usma MehmoodDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Aneeta HotwaniDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Ambreen NizarDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Furqan KabirDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Ronald J WongDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1205-6936
Martin BeckerDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-4296-3481
Eloise BersonDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1046-125X
Anthony CulosDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0083-6994
Davide De FrancescoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6185-0514
Samson MatarasoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3146-2243
Neal RavindraDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5558-3758
Melan ThuraiappahDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6412-6222
Maria XenochristouDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Ina A StelzerDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9974-4661
Ivana MarićDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9441-521X
Arup DuttaCentre for Public Health Kinetics, New Delhi, Delhi, India.ORCID 0000-0003-0602-0363
Rubhana RaqibInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0002-8116-4511
Salahuddin AhmedProjahnmo Research Foundation, Dhaka, Bangladesh.ORCID 0000-0001-6771-0638
Sayedur RahmanProjahnmo Research Foundation, Dhaka, Bangladesh.ORCID 0000-0002-4445-3699
A S M Tarik HasanProjahnmo Research Foundation, Dhaka, Bangladesh.
Said M AliPublic Health Laboratory-Ivo de Carneri, Pemba, Zanzibar, Tanzania.
Mohamed H JumaPublic Health Laboratory-Ivo de Carneri, Pemba, Zanzibar, Tanzania.
Monjur RahmanMaternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0002-7877-858X
Shaki AktarMaternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0002-8168-9721
Saikat DebCentre for Public Health Kinetics, New Delhi, Delhi, India.ORCID 0000-0001-8865-7194
Joan T PriceDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0003-4178-0405
Paul H WiseDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Virginia D WinnDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1136-2907
Maurice L DruzinDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7185-6664
Ronald S GibbsDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0776-6602
Gary L DarmstadtDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-7522-5824
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Jeffrey S A StringerDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-9590-7216
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3475-5706
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0784-7987
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1550-8136
Anisur RahmanMaternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0003-1033-5034
Abdullah H BaquiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-8350-1983
Fyezah JehanDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-5874-4358
Muhammad Imran NisarDepartment of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-2378-4720
Bellington VwalikaDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0001-5548-8187
Sunil SazawalCentre for Public Health Kinetics, New Delhi, Delhi, India.
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7438-4914
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6117-8764
Stanford University · USAga Khan University · PKInternational Centre for Diarrhoeal Disease Research · BDUniversity of North Carolina at Chapel Hill · USBiomedical Research Foundation · BDJohns Hopkins University · USPublic Health Laboratory Ivo de Carneri · TZColumbia University · USUniversity of Iowa · US
Funding
Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2MA Career Development Award in HIV-Associated Preterm Birth and its PreventionK01TW010857 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PRICE, JOAN · 2017 to 2021
$682kNeuromodulation of maternal immune adaptations in pregnancyK99HD105016 · NICHD · STANFORD UNIVERSITY · PI STELZER, INA · 2021 to 2022
$263kBill & Melinda Gates Foundation INV-005277FIC NIH HHS K01 TW010857NICHD NIH HHS K99 HD105016NIGMS NIH HHS R35 GM138353
Abstract
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets. Machine learning models showed robust performance for the prediction of PTB (AUROC = 0.70), time-to-delivery (
Indexed as
Premature BirthChemokines, CCChildDeveloping CountriesFemaleHumansInfant, NewbornMultiomicsPregnancyProteomicsChemokines, CC
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