SynthesisPloS one2023
A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Machine learning-based analysis of oral rinse samples to identify candidate proteomic signatures for severe periodontitis: a pilot study.Scientific reports · 2026Article
- Gingivitis Pathogenesis Involves Upregulation of Glycolysis and Citric Acid Cycle Activity Mediated by Bacterial Virulence Factors.International journal of molecular sciences · 2026Article
- Association of salivary proteins with periodontal disease in children and adolescents- a scoping review.BMC oral health · 2026Article
- Low salivary thioredoxin-1 levels in periodontitis.World journal of clinical cases · 2026Article
- Association Between Salivary Sirtuin-1 Levels and Periodontitis.Journal of clinical medicine · 2026Article
- Advanced Diagnostic Technologies and Molecular Biomarkers in Periodontitis: Systemic Health Implications and Translational Perspectives.Journal of clinical medicine · 2026Review
- Effect of non-surgical periodontal therapy on salivary pH, flow rate, salivary protein and calcium concentration in patients with chronic generalized periodontitis.Bioinformation · 2026Article
- High Salivary 3-Nitrotyrosine Levels in Periodontitis.Journal of clinical medicine · 2025Article
- The Precision Paradigm in Periodontology: A Multilevel Framework for Tailored Diagnosis, Treatment, and Prevention.Journal of personalized medicine · 2025Review
- Article
- High Salivary Malondialdehyde Levels Are Associated with Periodontitis Independently of Other Risk Factors.Journal of clinical medicine · 2025Article
- Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis.International dental journal · 2025Article
- CHANGES IN SALIVARY PROTEOME WITH REGARD TO PAIN-RELATED PROTEINS FOLLOWING FIXED ORTHODONTIC APPLIANCE PLACEMENT.Acta clinica Croatica · 2025Article
- Analytical validation of an automated assay to measure calprotectin (S100A8/A9) in dog saliva and serum and changes in canine leishmaniasis, pyometra and hyperadrenocorticism.BMC veterinary research · 2025Article
- Are Salivary and Plasma Levels of Toll-Like Receptors 2 and 4 Elevated in Subjects With Chronic Periodontitis?: A Systematic Review and Meta-Analysis.International journal of inflammation · 2025Review
- Salivary Th17 cytokine, human β-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease.Clinical oral investigations · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPeriodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures.
objectiveThis systematic review aims to present a robust critical evaluation of the evidence of salivary protein profiles for identifying oral diseases using proteomic approaches and summarize the use of these approaches to diagnose chronic periodontitis. DATA SOURCES: A systematic literature search was conducted from January 1st, 2010, to December 1st, 2022, based on PICO criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and by searching the three databases Science Direct, Scopus, and Springer Link. STUDY SELECTION: According to the inclusion criteria, eight studies were identified to analyze the proteins identified by proteomics.
resultsThe protein family S100 was identified as the most abundant in patients with chronic periodontitis. In this family, an increased abundance of S100A8 and S100A9 from individuals with the active disease was observed, which strongly relates to the inflammatory response. Moreover, the ratio S100A8/S100A9 and the metalloproteinase-8 in saliva could differentiate distinct periodontitis groups. The changes in protein profile after non-surgical periodontal therapy improved the health of the buccal area. The results of this systematic review identified a set of proteins that could be used as a complementary tool for periodontitis diagnosis using salivary proteins.
conclusionBiomarkers in saliva can be used to monitor an early stage of periodontitis and the progression of the disease following therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.