Evidence map›Paper›PMID 37223955›Full record

ArticleBiomacromolecules2023

Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.

Tanvi Jakkampudi, Qiao Lin, Saheli Mitra, Aishwarya Vijai, Weiheng Qin, Ann Kang, Jespar Chen, Emma Ryan, Runxuan Wang, Yuqi Gong and 4 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Tanvi JakkampudiBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Qiao LinDepartment of Environmental and Occupational Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-7017-8483
Saheli MitraBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Aishwarya VijaiBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Weiheng QinBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Ann KangBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Jespar ChenBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Emma RyanBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Runxuan WangBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Yuqi GongBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
Frank HeinrichNIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.
Junming SongDepartment of Environmental and Occupational Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.
Yuan-Pu Peter DiDepartment of Environmental and Occupational Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0003-2028-2087
Stephanie Tristram-NagleBiological Physics, Physics Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0003-2271-7056
Carnegie Mellon University · USUniversity of Pittsburgh · USNational Institute of Standards and Technology · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Novel antimicrobial agents to overcome antibiotic resistant Pseudomonas and MRSA respiratory infectionR01AI133351 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DI, YUANPU PETER · 2017 to 2021
$2.6M
Membrane Coupling and Dynamic Reorganization of Gag in Viral BuddingR01GM101647 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI LOESCHE, MATHIAS · 2012 to 2015
$1.2M
NIAID NIH HHS R01 AI133351NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R01 GM101647
6 · The paper itself

Abstract

SPLUNC1 (short palate lung and nasal epithelial clone 1) is a multifunctional host defense protein found in human respiratory tract with antimicrobial properties. In this work, we compare the biological activities of four SPLUNC1 antimicrobial peptide (AMP) derivatives using paired clinical isolates of the Gram-negative (G(-)) bacteria

Indexed as

BacteriaLungBiofilmsGlycoproteinsGram-Negative BacteriaHumansLipidsMicrobial Sensitivity TestsPeptidesPhosphoproteinsBPIFA1 protein, humanGlycoproteinsLipidsPeptidesPhosphoproteins

Identifiers

PMID37223955
PMCPMC10265666
OpenAlexW4377939950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.