Evidence map›Paper›PMID 37223953›Full record

ArticleJournal of virology2023

Experimental Support for Human Papillomavirus Genome Amplification Early after Infectious Delivery.

Katarzyna Zwolinska, Malgorzata Bienkowska-Haba, Rona S Scott, Timothy Keiffer, Martin Sapp

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katarzyna ZwolinskaDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA.
Malgorzata Bienkowska-HabaDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA.
Rona S ScottDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA.ORCID 0000-0003-3840-9189
Timothy KeifferDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA.
Martin SappDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA.ORCID 0000-0003-3916-8890
Louisiana State University Health Sciences Center Shreveport · US

Funding

The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
Immediate early events of the HPV life cycleR01CA211576 · NCI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Katarzyna Zwolinska · 2017 to 2026
$2.8M
Epigenetic Effects of Epstein-Barr Virus Infection in Oral Squamous Cell CarcinomaR01DE025565 · NIDCR · LOUISIANA STATE UNIV HSC SHREVEPORT · PI SCOTT, RONA S · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA211576NIAID NIH HHS P01 AI127335NIDCR NIH HHS R01 DE025565NIGMS NIH HHS P20 GM134974
6 · The paper itself

Abstract

Even though replication and transcription of human papillomavirus type 16 (HPV16) has been intensively studied, little is known about immediate-early events of the viral life cycle due to the lack of an efficient infection model allowing genetic dissection of viral factors. We employed the recently developed infection model (Bienkowska-Haba M, Luszczek W, Myers JE, Keiffer TR, et al. 2018. PLoS Pathog 14:e1006846) to investigate genome amplification and transcription immediately after infectious delivery of viral genome to nuclei of primary keratinocytes. Using 5-ethynyl-2'-deoxyuridine (EdU) pulse-labeling and highly sensitive fluorescence

Indexed as

Genome, ViralHuman papillomavirus 16Papillomavirus InfectionsAnimalsCell LineDNA-Binding ProteinsHEK293 CellsHumansMiceNIH 3T3 CellsOncogene Proteins, ViralViral TranscriptionVirus ReplicationDNA-Binding ProteinsE1 protein, Human papillomavirus 16E2 protein, Human papillomavirus type 16Oncogene Proteins, ViralDNA amplificationDNA replicationE1E2E8^E2HPV16infection modelprimary foreskin keratinocytesviral genome amplificationviral genome copy numberviral transcription

Identifiers

PMID37223953
PMCPMC10308938
OpenAlexW4377029569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.