Evidence map›Paper›PMID 37223477›Full record

ArticleResearch (Washington, D.C.)2023

Striatal CDK5 Regulates Cholinergic Neuron Activation and Dyskinesia-like Behaviors through BK Channels.

Chu Tong, Peng-Xiang Min, Qian Zhang, Ru-Xin Gu, Yao-Hai Wen, Yi Shi, Yu-Huan Bao, Xiang Chen, Yi-Xuan Zhang, Xing-Feng Mao and 6 more

Open access · goldAbstract read
In one paragraph

Article in Research (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Upregulated inwardly rectifying KJournal of biomedical research · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Chu TongDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Peng-Xiang MinInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Qian ZhangDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Ru-Xin GuDepartment of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Yao-Hai WenDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Yi ShiDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Yu-Huan BaoInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Xiang ChenInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Yi-Xuan ZhangInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Xing-Feng MaoDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Hao-Yang YuanDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Xiu-Xiu LiuInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Takuya SasakiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Li ZhangDepartment of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Feng HanInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Ying-Mei LuDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Nanjing Medical University · CNNanjing Brain Hospital · CNTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbance of the cholinergic system plays a crucial role in the pathological progression of neurological diseases that cause dyskinesia-like behaviors. However, the molecular mechanisms underlying this disturbance remain elusive. Here, we showed that cyclin-dependent kinase 5 (

Identifiers

PMID37223477
PMCPMC10202382
OpenAlexW4361218922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.