Evidence map›Paper›PMID 37223043›Full record

ArticleFrontiers in endocrinology2023

Baseline level and change trajectory of the triglyceride-glucose index in relation to the development of NAFLD: a large population-based cohort study.

Yaqin Wang, Jiangang Wang, Lei Liu, Pingting Yang, Shuwen Deng, Xuelian Liu, Linlin Zhao, Changfa Wang, Ying Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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  10. Association between triglycerideZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yaqin WangHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiangang WangHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lei LiuHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Pingting YangHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shuwen DengHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xuelian LiuHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Linlin ZhaoHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Changfa WangGeneral Surgery Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ying LiHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD) are closely related. The triglyceride-glucose index (TyG index) has been proposed as a new indicator of IR. It remains unclear whether the triglyceride-glucose (TyG) index is prospectively associated with incident nonalcoholic fatty liver disease (NAFLD). Methods: This large-scale study comprised 1 prospective cohort totaling 22,758 subjects without NAFLD at baseline who underwent repeated health examinations and 1 subcohort totaling 7,722 subjects with more than three visits. The TyG index was ascertained mathematically by ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). NAFLD was diagnosed by ultrasound without other concomitant liver diseases. A combinatorial Cox proportional hazard model and latent class growth mixture modeling method were used to identify the association of the TyG index and its transition trajectories with NAFLD risk. Results: During 53,481 person-years of follow-up, there were 5319 incident cases with NAFLD. Compared with those in the lowest quartile of the baseline TyG index, participants in the highest quartile had 2.52-fold (95% confidence interval, 2.21-2.86) higher odds of incident NAFLD. Similarly, restricted cubic spline analysis showed a dose-response relationship ( Conclusions: Participants with a higher baseline TyG index or a higher excessive TyG exposure were associated with an increased NAFLD risk. The findings imply that lifestyle interventions and modulation of IR might be considered to both reduce TyG index levels and prevent NAFLD development.

Indexed as

Insulin ResistanceNon-alcoholic Fatty Liver DiseaseCohort StudiesFemaleGlucoseHumansProspective StudiesTriglyceridesGlucoseTriglyceridescohort studyinsulin resistancenon-alcoholic fatty liver diseaserisk factorstriglyceride glucose index

Identifiers

PMID37223043
PMCPMC10200880
OpenAlexW4375864335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.