Evidence map›Paper›PMID 37223037›Full record

ReviewFrontiers in endocrinology2023

A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk.

LillyBelle K Deer, Chen Su, Natalie A Thwaites, Elysia Poggi Davis, Jenalee R Doom

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

LillyBelle K DeerDepartment of Psychology, University of Denver, Denver, CO, United States.
Chen SuDepartment of Psychology, University of Denver, Denver, CO, United States.
Natalie A ThwaitesDepartment of Psychology, University of Denver, Denver, CO, United States.
Elysia Poggi DavisDepartment of Psychology, University of Denver, Denver, CO, United States.
Jenalee R DoomDepartment of Psychology, University of Denver, Denver, CO, United States.
University of Denver · USUniversity of California, Irvine · US

Funding

Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular healthK01HL143159 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DOOM, JENALEE RAE · 2019 to 2023
$788k
Placental CRH and child cardiovascular disease risk and obesogenic eating behaviorsF32HL165844 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEER, LILLYBELLE KUULEI · 2022 to 2024
$165k
NHLBI NIH HHS F32 HL165844NHLBI NIH HHS K01 HL143159NHLBI NIH HHS R01 HL155744NIMH NIH HHS R01 MH109662
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adulthood, but little is known about relations between prenatal stress-responsive hormones and early precursors of CVD, such as cardiometabolic risk and health behaviors. The current review presents a theoretical model of the relation between prenatal stress-responsive hormones and adult CVD through cardiometabolic risk markers (e.g., rapid catch-up growth, high BMI/adiposity, high blood pressure, and altered blood glucose, lipids, and metabolic hormones) and health behaviors (e.g., substance use, poor sleep, poor diet and eating behaviors, and low physical activity levels). Emerging evidence in human and non-human animal literatures suggest that altered stress-responsive hormones during gestation predict higher cardiometabolic risk and poorer health behaviors in offspring. This review additionally highlights limitations of the current literature (e.g., lack of racial/ethnic diversity, lack of examination of sex differences), and discusses future directions for this promising area of research.

Indexed as

Cardiovascular DiseasesHypertensionAdiposityAnimalsBlood GlucoseFeeding BehaviorFemaleMalePregnancyBlood Glucosecardiometabolic riskcardiovascular disease (CVD)cortisolhealth behaviorsplacental CRH

Identifiers

PMID37223037
PMCPMC10200937
OpenAlexW4377940338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.