Evidence map›Paper›PMID 37223028›Full record

ArticleFrontiers in endocrinology2023

Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.

Nelmari Ruiz-Otero, Rejji Kuruvilla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nelmari Ruiz-OteroDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rejji KuruvillaDepartment of Biology, Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Neurotrophin mechanisms in neural development and diseaseR01NS073751 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2011 to 2015
$1.7M
Neurotrophic factor trafficking and signaling in development and diseaseR01NS107342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2019 to 2022
$1.7M
NINDS NIH HHS R01 NS073751NINDS NIH HHS R01 NS107342
6 · The paper itself

Abstract

Cell-cell interactions are necessary for optimal endocrine functions in the pancreas. β-cells, characterized by the expression and secretion of the hormone insulin, are a major constituent of functional micro-organs in the pancreas known as islets of Langerhans. Cell-cell contacts between β-cells are required to regulate insulin production and glucose-stimulated insulin secretion, which are key determinants of blood glucose homeostasis. Contact-dependent interactions between β-cells are mediated by gap junctions and cell adhesion molecules such as E-cadherin and N-CAM. Recent genome-wide studies have implicated Delta/Notch-like EGF-related receptor

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2AdultAnimalsCadherinsEpidermal Growth FactorHomeostasisHumansInsulinMiceBlood GlucoseCadherinsEpidermal Growth FactorInsulincell-adhesionDNERN-CAMpancreatic isletsβ-cell

Identifiers

PMID37223028
PMCPMC10200888
OpenAlexW4375866869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.