Evidence map›Paper›PMID 37222972›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2023

Simple bedside tests of muscle strength and function correlate with computed tomography-skeletal muscle index for assessment of sarcopenia in cirrhosis.

Surender Singh, Sunil Taneja, Akash Roy, Sahaj Rathi, Arka De, Nipun Verma, Madhumita Premkumar, Ajay Duseja, R K Dhiman, Virendra Singh

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Surender SinghDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Sunil TanejaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India. drsuniltaneja@hotmail.com.
Akash RoyDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Sahaj RathiDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Arka DeDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Nipun VermaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Madhumita PremkumarDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Ajay DusejaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
R K DhimanDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Virendra SinghDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia assessment can be done by skeletal muscle index (SMI) or bedside tests such as handgrip strength (HGS) and gait speed (GS). GOALS: This study evaluated the correlations of HGS and GS with SMI, health-related quality of life (HRQOL) and cognition and assessed them as predictors of mortality. STUDY: As many as 116 outpatients with cirrhosis were included in this prospective cohort study. Assessment for sarcopenia was done by SMI, HGS and GS. HRQOL was assessed using the chronic liver disease questionnaire (CLDQ) and fatigue severity scale (FSS). Cognition was assessed by mini-mental state examination (MMSE). Correlations of HGS and GS with SMI, HRQOL and cognition were analyzed. Area under the curve (AUCs) were calculated to compare them as predictors of mortality.

resultsAlcoholic liver disease (47.4%) was the commonest etiology of cirrhosis followed by hepatitis C (12.9%). Sarcopenia was diagnosed in 64 (55.2%) patients. A strong correlation was seen between SMI and HGS (ρ = 0.78) and GS (ρ = 0.65). AUCs of GS (0.91 (95% confidence interval [CI], 0.85-0.96) was maximum, followed by HGS (95% CI, 0.86 [0.78-0.93] and SMI [95% CI, 0.8 0.71-0.88]) in predicting mortality (p > 0.05). CLDQ (3.2 vs. 5.6, p < 0.01) and MMSE scores (24.3 vs. 26.3, p < 0.01) were lower, whereas FSS score (5.7 vs. 3.1, p < 0.01) was higher in patients with sarcopenia. CLDQ (ρ = 0.83) and MMSE (ρ = 0.73) showed the strongest correlation with HGS, whereas FSS correlated well (ρ = 0.77) with GS.

conclusionsBedside tests of muscle strength and function, including HGS and GS, correlate strongly with SMI for sarcopenia assessment and prediction of mortality in patients with cirrhosis.

Indexed as

SarcopeniaHand StrengthHumansLiver CirrhosisMuscle, SkeletalMuscle StrengthProspective StudiesQuality of LifeTomography, X-Ray ComputedAssessmentBedside testsCirrhosisCognitionGait speedHandgrip strengthMuscle functionMuscle massMuscle strengthSarcopeniaSkeletal muscle index

Identifiers

PMID37222972
OpenAlexW4377938856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.