ArticlePediatric nephrology (Berlin, Germany)2023
A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.
Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Impact of post-filter ionized calcium target range on circuit survival and citrate-related complications in pediatric continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Safety and efficacy of low-dose initial citrate infusion for continuous kidney replacement therapy in critically ill children.Pediatric nephrology (Berlin, Germany) · 2026Article
- Fulminant Hepatitis Due to Enterovirus E25 Systemic Infection in a Pediatric Patient.Pathogens (Basel, Switzerland) · 2026Article
- Efficacy and safety of a novel 18 mmol/L sodium citrate hemofiltration solution in continuous renal replacement therapy for critically ill patients: a retrospective cohort study.Translational andrology and urology · 2026Article
- Article
- Evaluation of anticoagulant methods in newborns undergoing continuous renal replacement therapy: what is the optimum method?European journal of pediatrics · 2025Article
- Effect of sodium citrate anticoagulant solution in continuous veno-venous hemofiltration in critically ill children.BMC pediatrics · 2025Article
- Factors influencing circuit lifetime in paediatric continuous kidney replacement therapies - results from the EurAKId registry.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Citrate anticoagulation and systemic heparin anticoagulation during continuous renal replacement therapy among critically-ill children.Pediatric research · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRegional citrate anticoagulation (RCA) is the preferred modality of anticoagulation used in continuous kidney replacement therapy (CKRT) in adults and less extensively in children. Potential metabolic complications limit widespread use in infants, neonates, and in children with liver failure.
methodsWe report our experience with a simplified protocol in 50 critically ill children, infants, and neonates, some of them with liver failure, with commercially available solutions containing phosphorous and higher concentration of potassium and magnesium.
resultsRCA allowed attainment of a mean filter lifetime of 54.5 ± 18.2 h, 42.5% of circuits lasted more than 70 h, and scheduled change was the most frequent cause of CKRT interruption. Patient Ca
conclusionsIn our experience, RCA with commercially available solutions was easily applied and managed in critically ill children, even in patients with low weight or with liver failure. Solutions containing phosphate and higher concentrations of magnesium and potassium allowed reduction of metabolic derangement during CKRT. Prolonged filter life was ensured with no detrimental effects on patients and reduced staff workload. A higher resolution version of the Graphical abstract is available as Supplementary information.
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