Evidence map›Paper›PMID 37222842›Full record

ArticleJournal of neurology2023

Reduced

Junya Ebina, Sunao Mizumura, Nobutomo Ishii, Yukio Kobayashi, Mari Shibukawa, Harumi Morioka, Junpei Nagasawa, Masaru Yanagihashi, Takehisa Hirayama, Kiyokazu Kawabe and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Value of multi-parameterEJNMMI research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Junya EbinaDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Sunao MizumuraDepartment of Radiology, Toho University Faculty of Medicine, Tokyo, Japan.
Nobutomo IshiiCentral Radiology Division, Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan.
Yukio KobayashiDepartment of Radiological Technology, Kanto Central Hospital, Tokyo, Japan.
Mari ShibukawaDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Harumi MoriokaDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Junpei NagasawaDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Masaru YanagihashiDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Takehisa HirayamaDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Kiyokazu KawabeDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan.
Satoshi OrimoKamiyoga Setagaya Street Clinic, Tokyo, Japan.
Osamu KanoDepartment of Neurology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, Japan. osamu.kano@med.toho-u.ac.jp.ORCID http://orcid.org/0000-0003-3748-3694
Toho University · JPKanto Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze

methodsWe recruited 77 patients with PD and 21 age-matched controls. We assessed MIBG scintigraphy in the major salivary glands and myocardium. We calculated the MIBG uptake ratio in the parotid glands/mediastinum (P/M), submandibular glands/mediastinum (S/M), and heart/mediastinum (H/M) using a quantitative semi-automatic method. We investigated the correlations between MIBG uptake and clinical features.

resultsThe P/M and H/M ratios in the early and delayed phases were significantly reduced in PD patients compared to controls, while the delayed phase S/M ratio was reduced in PD patients compared to controls. The P/M ratio correlated with the S/M ratio, while neither the P/M nor S/M ratio correlated with the H/M ratio. Between PD patients and controls, sensitivity and specificity were 54.8% and 59.1% for the delayed phase P/M ratio, while sensitivity and specificity were 59.5% and 61.0% for the delayed phase S/M ratio, respectively. Furthermore, sensitivity and specificity for the delayed phase H/M ratio were 85.7% and 79.2, respectively.

conclusionMIBG uptake in the parotid and submandibular glands was reduced in patients with PD. Furthermore, sympathetic denervation in the major salivary glands and myocardium might progress independently. Our findings suggest a new aspect of the pathological distribution of PD.

Indexed as

3-IodobenzylguanidineParkinson DiseaseHeartHumansIodine RadioisotopesParotid GlandRadiopharmaceuticalsSubmandibular Gland3-IodobenzylguanidineIodine-123Iodine RadioisotopesRadiopharmaceuticalsAutonomic dysfunctionMajor salivary glandsMIBG scintigraphyMyocardiumParkinson’s disease

Identifiers

PMID37222842
OpenAlexW4377940271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.